Antihyperglycemic and hypolipidemic potential of Caesalpinia decapetala in alloxan-induced diabetic rabbits

Authors

  • Liaqat Hussain College of Pharmacy, GC University, Faisalabad
  • Muhammad Imran Qadir Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan
  • Shafiq-ur- Rehman College of Pharmacy, GC University, Faisalabad

DOI:

https://doi.org/10.3329/bjp.v9i4.19961

Keywords:

Antihyperglycemic, Caesalpinia decapetala, Diabetes mellitus, Lipidemia

Abstract

The anti-hyperglycemic, anti-hyperlipidemic, kidney and hepatoprotective potential of Caesalpinia decapetala were evaluated in alloxan-induced diabetic rabbits. The plant extract showed concentration dependant significant (p<0.001) therapeutic potential in diabetic rabbits revealing improvement in lipid profile and liver and kidney functions. 300 mg/kg and 500 mg/kg oral extract were able to reduce average blood glucose levels from 250.6 mg/dL to 204.2 mg/dL and 188.2 mg/dL respectively during 14 days period, in comparison to 183.8 mg/dL of glibenclamide. There was no significant synergistic effect found, upon co-administration of both drug and extract representing the competitive binding to sulphonyl urea (SUR1), revealing possible mechanism of action for compounds in extract. Extract was found to be nephroprotective, hepatoprotective and improved lipid profile of alloxan-treated rabbits.

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Author Biography

Muhammad Imran Qadir, Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan

Assistant Professor

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Published

2014-10-25

How to Cite

Hussain, L., M. I. Qadir, and S.- ur-. Rehman. “Antihyperglycemic and Hypolipidemic Potential of Caesalpinia Decapetala in Alloxan-Induced Diabetic Rabbits”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 529-32, doi:10.3329/bjp.v9i4.19961.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

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