Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer

Authors

  • Guo-Fang Guan Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • De-Jun Zhang Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • Ding Xin Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • Lian-Ji Wen Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • Duo-Jiao Yu Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • Yan-Qing Lu Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • Yan Zhao Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041
  • Tie-Jun Wang Department of Radiation Oncology, The Second Hospital of Jilin University, Changchun 130 041

DOI:

https://doi.org/10.3329/bjp.v9i4.20342

Keywords:

Anticancer drug, Antiproliferative drug, Cancer, Stem cell, Verapamil

Abstract

Activation of Notch signaling pathway in cancer stem cells plays a crucial role in the regulation of selfrenewal and maintenance of side population cells.  In the present study, we have identified cancer stem like 2.7% side population cells from nasopharyngeal carcinoma samples whose prevalence was significantly reduced to 0.3% upon verapamil treatment. The protein level of Notch1 and Hes-1 are highly up-regulated in fluorescence-activated cell sorting purified side population cells and thus leads to the elevated expression of stem cell surface proteins (Oct-4, Sox2 and Nanog), which are essential for side population cells self-renewal. In addition, these nasopharyngeal carcinoma side population cells are CD133 and CD44 positive and they possess enhanced cell proliferation rate, highly tumorgenic and invasive. Our findings suggest that Notch1 signaling is a potential target of novel anticancer drugs, which could efficiently target and eradicate the cancer stem cells.

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Published

2014-10-31

How to Cite

Guan, G.-F., D.-J. Zhang, D. Xin, L.-J. Wen, D.-J. Yu, Y.-Q. Lu, Y. Zhao, and T.-J. Wang. “Notch 1 Signaling Pathway Is the Potential Target of Novel Anticancer Drugs for the Treatment of Human Nasopharyngeal Cancer”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 557-66, doi:10.3329/bjp.v9i4.20342.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

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