Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats

Authors

  • Yun-Fei Shuai Department of Pediatrics, the First Affiliated Hospital of Hunan Traditional Chinese Medicine University, Changsha 410007, China.
  • Meng-Qing Wang Department of Pediatrics, the First Affiliated Hospital of Hunan Traditional Chinese Medicine University, Changsha 410007, China.
  • Le-Qin Xiong State Key Laboratory of Medical Genetics Life Science and Technology College, Central South University
  • Lin Liu Department of Pediatrics, Xiangya Third Hospital of Central South University, Changsha 410013, China
  • Yin-He Luo Department of Pediatric Integrative Medicine, Hunan Traditional Chinese Medicine University, Changsha 410208, China
  • Tian-Shu Peng Department of Anorectal, the Second Affiliated Hospital of Hunan Traditional Chinese Medicine University, Changsha 410005, China

DOI:

https://doi.org/10.3329/bjp.v9i4.20534

Keywords:

Vitamin C, isoflurane, neuronal apoptosis, neurotoxicity

Abstract

Developmental abnormalities, neuronal apoptosis and associated cognitive impairment following isoflurane exposure in neonatal rodents have been reported. The study was undertaken to investigate the effect of vitamin C supplementation against isoflurane-induced neurotoxicity. Seven day old rats were exposed to 1.1% isoflurane, or air for 6 hours. Treatment groups were administered with vitamin C (30 mg/kg, orally) from postnatal day 1 (P1) to P10 and were exposed to isoflurane on P7. Isoflurane exposure induced apoptosis was determined by Fluoro-Jade C and terminal deoxynucleotidyl-transferase-mediated 2-deoxyuridine 5-triphosphate nick-end labeling assay. Vitamin C considerably improved memory and learning impairments, modulated neuroapoptosis and improved expressions of brain-derived neurotrophic factor, nerve growth factor, Bcl-xL and decreased activated caspase-3 expressions. Thus, vitamin C effectively offered protection against isoflurane-induced neuronal apoptosis, learning and memory disturbances.

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Published

2014-11-16

How to Cite

Shuai, Y.-F., M.-Q. Wang, L.-Q. Xiong, L. Liu, Y.-H. Luo, and T.-S. Peng. “Effects of Vitamin C on Inhalation Anesthetic Isoflurane-Induced Developmental, Neuronal Apoptosis in Neonatal Rats”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Nov. 2014, pp. 580-7, doi:10.3329/bjp.v9i4.20534.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

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