Antimicrobial activity of ethanolic extracts of Justicia neesii

Authors

  • Sridhar Nimmakayala Department of pharmacology, Pydah College of Pharmacy, Kakinada, A.P
  • Suguna Lakshmi Duggirala Department of pharmacology, Pydah College of Pharmacy, Kakinada, A.P
  • Goverdhan Puchchakayala Department of Pharmacology, Vaagdevi College of Pharmacy, Hanamkonda, Thelangana

DOI:

https://doi.org/10.3329/bjp.v9i4.20571

Keywords:

Antimicrobial, Justicia neesii

Abstract

Agar well diffusion method was used to evaluate the antimicrobial potential of Justicia  neesii extract. The maximum activity index (AI) values are observed against Klebsiella pneumonia (1.208) and low AI value for Streptococcus faecalis (0.963) compared to other bacterial species. The maximum AI values are observed against Saccharomyces cerevisiae (1.147) and low AI value for Fusarium axisporum (0.986) compared to other fungal species. The MIC and MBC/MFC values indicated the bacteriostatic/ fungistatic nature of the extract and also having good correlation with the zone of inhibition values. The total activity values indicated that J. neesii extract can show antimicrobial activity even at higher dilutions, except for Gram negative bacteria.

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References

Eloff JN. Quantifying the bioactivity of the plant extracts during screening and bioassay guided fractionation. Phytomedicine 2004; 11: 370-71.

Gopalaiah K, Kavitha J, Kanumuri RV, Rajasekhar D, Subbaraju GV. Justicia lignans: Part 9- Two new lignans from Justicia neesii Ramamoorthy. (White flower variety). Indian J Chem. 2001; 40B: 596-600.

Jeyaseelan EC, Jashothan PTJ. In vitro control of Staphylococcus aureus (NCTC 6571) and Escherichia coli (ATCC 25922) by Ricinus communis L. Asian Pac J Trop Biomed. 2012; 2: 717–21.

Khan NA. In vitro antimicrobial activity of triterpenoid saponin from Tephrosia purpurea seeds extract. Eur J Chem. 2011; 2: 189‐92.

Mcfarland J, Jama MD. The nephelometer: An instrument for estimating the number of bacteria in suspensions used for calculating the opsonic index and for vaccines. JAMA 1907; 14: 1176.

Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolke RH. Manual of clinical microbiology. 6th ed. London, Mosby Year Book, 1995.

Pelczer MJ, Chan ECS, Noel RK. Microbiology. 4th ed. India, Tata McGraw Hill, 1998.

Perez C, Paul M, Bazerque P. An antibiotic assay by the agar-well diffusion method. Acta Biol Med Exp. 1990; 15: 113-15.

Prasannabalaji N, Muralitharan G, Sivanandan RN, Kumaran S, Pugazhvendan SR. Antibacterial activities of some Indian traditional plant extracts. Asian Pac J Trop Dis. 2012; S291-95.

Rajasekhar D, Subbaraju GV. Justicia lignans- V. Three new beta-apolignans from Justicia neesii Ramamoorthy. Tetrahedron 1998; 54: 13227-36.

Rajasekhar D, Vanisree M, Subbaraju GV. Justicia lignans: Part 4- Two new arylnaphthalide lignans from Justicia neesii Ramamoorthy. Indian J Chem. 1999; 38B: 713-17.

Shabir G, Anwar F, Sultana B, Khalid ZM, Afzal M, Khan QM, Ashrafuzzaman M. Anti-oxidant and antimicrobial attributes and phenolics of different solvent extracts from leaves, flowers and bark of gold mohar [Delonix regia (Bojer ex Hook.) Raf]. Molecules 2011; 16: 7302-19.

Subbaraju GV, Rajasekhar D, Kavitha J, Jimenez JI. Justicia lignans: Part 7-Two new diphyllin glycosides from Justicia neesii ramamoorthy. Indian J Chem. 2001; 40B: 313-19.

Vasilev NP, Ionkova I. Cytotoxic activity of extracts from Linum cell cultures. Fitoterapia 2005; 76: 50-53.

Published

2014-11-26

How to Cite

Nimmakayala, S., S. L. Duggirala, and G. Puchchakayala. “Antimicrobial Activity of Ethanolic Extracts of Justicia Neesii”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Nov. 2014, pp. 624-7, doi:10.3329/bjp.v9i4.20571.

Issue

Section

Research Articles