Retinoic acid triazole promotes neurotrophin-mediated cell growth and proliferation in nerve cells
DOI:
https://doi.org/10.3329/bjp.v9i4.20645Keywords:
neurotrophin, neurite growth activity, brain derived nerve growth factor, bioavailabilityAbstract
In the present study, fluorophenyl retinoic acid triazole, a retinoic acid derivative having more bioavailability compared to the parent retinoic acid was investigated against cell growth and proliferation. The results indicated that fluorophenyl retinoic acid triazole leads to a significant expression of TRK mRNA in time a dependent manner in NB1643 cells. There were about 10-, 14-, and 21-fold induction of expression after 1, 2, and 3 days of treatment, respectively. The results revealed that TRK and TRKB were induced at 6 and 12 hours afterthe treatment respectively and the expression of TRKB was maximum at day 3. Fluorophenyl retinoic acid triazole exerts neurite outgrowth activity by inducing TRKB expression, which is a receptor for brain-derived neurotrophic factor and a protein-tyrosine kinase. Fluorophenyl retinoic acid triazole accumulation generates many small vesiclesin the cell which assembles at the neck of each small prominence and lead to significant morphological changes after 24 hours of treatment.
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Ahmed S, Reynolds BA, Weiss S. BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors. J Neurosci. 1995; 15: 5765–78.
Altar CA, Whitehead RE, Chen R, W¨ortwein G, Madsen TM. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry. 2003; 54: 703–09.
Butler WB. Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle. Anal Biochem. 1984; 141: 70–73.
Corcoran J, So PL, Maden M. Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients. J Cell Sci. 2002; 115: 4735–41.
Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry. 2001; 50: 260–65.
Christie VB, Maltman DJ, Henderson AP, Whiting A, Marder TB, Lako M, Przyborski SA. Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro. J Neurosci Meth. 2010; 193: 239–45.
Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S. Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol. 2010; 70: 271–88.
Dwivedi Y. Brain-derived neurotrophic factor: Role in depression and suicide. Neuropsychiatric Dis Treat. 2009; 5: 433–49.
Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci. 2005; 255: 381-86.
Goodman AB. Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proc Natl Acad Sci. 1998; 95: 7240–44.
Guan K, Chang H, Rolletschek A, Wobus A. Embryonic stem cell derived neurogenesis: Retinoic acid induction and lineage selection of neuronal cells. Cell Tissue Res. 2001; 305: 171–76.
Huang EJ, Reichardt LF. Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci. 2001; 24: 677–736.
Jiang X, Cao HQ, Shi LY, Ng SY, Stanton LW, Chew SY. Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment. Acta Biomater. 2012; 8: 1290–302.
Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002; 109: 143–48.
Kim YK, Won SD, Hur JW, Lee BH, Lee HY, Shim SH, Han SW, Choi SH. Exploration of biological markers of suicidal behavior in major depressive disorder. Psychiatry Investig. 2007; 4: 13–21.
Krezel W, Ghyselinck N, Samad TA, Dupé V, Kastner P, Borrelli E, Chambon P. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 1998; 279: 863–67.
Kirschenbaum B, Goldman SA. Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc Natl Acad Sci. 1995; 92: 210–14.
Lang UE, Bajbouj M, Gallinat J, Hellweg R. Brain derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation. Psychopharmacology 2006; 187: 56–59.
Lee BH, Kim YK. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investig. 2010; 7: 231-35.
Lee Y, Lim SW, Kim SY, Chung JW, Kim J, Myung W, Song J, Kim S, Carroll BJ, Kim DK. Association between the BDNF Val66Met polymorphism and chronicity of depression. Psychiatry Investig. 2013; 10: 56–61.
Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci. 2007; 8: 755–65.
Maden M. Retinoid signalling in the development of the central nervous system. Nat Rev Neurosci. 2002; 3: 843–53.
M¨uller MB, Toschi N, Kresse AE, Post A, Keck ME. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsycho-pharmacology 2000; 23: 205-15.
Nojehdehian H, Moztarzadeh F, Baharvand H, Nazarian H, Tahriri M. Preparation and surface characterization of poly-L-lysine-coated PLGA microsphere scaffolds containing retinoic acid for nerve tissue engineering: In vitro study. Colloid Surf B-Biointerfaces. 2009; 73: 23–29.
Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Zhang H, Pavuluri MN. Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects. Prog Neuro-Psychopharmacol Biol Psychiatry. 2010; 34: 645–51.
Pencea V, Bingaman KD, Wiegand SJ, Luskin MB. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci. 2001; 21: 6706–17.
Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 1995; 15: 1768-77.
Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Anti-depressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Be. 1996; 56: 131-37.
Shirayama Y, Chen ACH, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci. 2002; 22: 3251–61
Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, HaapasaloA, Nawa H, Aloyz R, Ernfors P, Castren E. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci. 2003; 23: 349-57.
Tripp A, Oh H. Guilloux JP, Martinowich K, Lewis DA, Sibille E. Brain-derived neurotrophic factor signalling and sub-genual anterior cingulate cortex dysfunction in major depressive disorder. Am J Psychiatry. 2012; 169: 1194–202.
Vutskits L, Djebbara-Hannas Z, Zhang H, Paccaud JP, Durbec P, Rougon G, Muller D, Kiss JZ. PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons. Eur J Neurosci. 2001; 13: 1391–402.
Waterhouse EG, Xu B. New insights into the role of brain-derived neurotrophic factor in synaptic plasticity. Mol Cell Neurosci. 2009; 42: 81–89.
Xu J, Wang H, Liang T, Cai X, Rao X, Huang Z, Sheng G. Retinoic acid promotes neural conversion of mouse embryonic stem cells in adherent monoculture. Mol Biol Rep. 2012; 39: 789–95.
Zigova T, Pencea V, Wiegand SJ, Luskin MB. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 1998; 11: 234–45.
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