Medicinal plants in the protection and treatment of liver diseases

Authors

  • Mohammad Saleem College of Pharmacy, G. C. University Faisalabad, Faisalabad
  • Faiza Naseer College of Pharmacy, G. C. University Faisalabad, Faisalabad

DOI:

https://doi.org/10.3329/bjp.v9i4.20648

Keywords:

Carbon tetrachloride, Hepatotoxicity, Herbs, Paracetamol

Abstract

Hepatic dysfunction is globally a major health catastrophe that challenges the health care professionals. The existing synthetic drugs to treat liver diseases have not given much pronounced outcomes. So, conventional herbal plants have become progressively more popular and their utilization is more prevalent. The current review is assemblage of few promising medicinal plants used in the protection and treatment of various liver diseases. Extracts of plants ground significant alteration in liver marker enzymes against diverse hepatotoxic agents.

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References

Achuthan CR, Babu BH, Padikkala J. Antioxidant and hepatoprotective effects of Rosa damascena. Pharmaceut. Biol. 2003. 41: 357-61.

Afaf A, Nuha HS, Mohammed AH. Hepatoprotective effect of Lepidium sativum against carbon tetrachloride induced damage in rats. Res J Ani Vet Sci. 2008; 3: 20-28.

Ahmad M, Erum S. Hepatoprotective studies on Haloxylon salicornicum: A plant from Cholistan desert. Pak J Pharmac Sci. 2011; 24: 377-82.

Ahmad M, Mahmood Q, Gulzar K, Akhtar MS, Saleem M, Qadir MI. Antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in alloxan-induced diabetic rabbits (Oryctolagus cuniculus). Pak Vet J. 2011; 32: 50-54.

Ahmed B, Alam T, Khan SA. Hepatoprotective activity of Luffa echinata fruits. J Ethnopharmacol. 2001; 76: 187-89.

Ahsan MR, Islam KM, Bulbul IJ. Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride-induced hepatotoxicity in rats. Eur J Sci Res. 2009; 37: 302-10.

Alamgeer, Nawaz M, Ahmad T, Mushtaq MN, Batool A. Hepatoprotective activity of Thymus linearis against paracetamol and carbon tetrachloride-induced hepatotoxicity in albino mice. Bangladesh J Pharmacol. 2014; 9: 230-34.

Ali M, Qadir MI, Saleem M, Janbaz KH, Gul H, Hussain L, Ahmad B. Hepatoprotective potential of Convolvulus arvensis against paracetamol-induced hepatotoxicity. Bangladesh J Pharmacol. 2013; 8: 300-04.

Al-Razzuqi R, Al-Jawad F, Al- Hussaini J, Al-Jeboori A. Hepatoprotective effect of Glycyrrhiza glabra in carbon tetrachloride-induced model of acute liver injury. J Phys Pharm Adv. 2012; 2: 259-63.

Anusuya N, Raju K, Manian S. Hepatoprotective and toxicological assessment of an ethnomedicinal plant Euphorbia fusiformis Buch.-Ham. J Ethnopharmacol. 2010; 127: 463-67.

Arsul VA, Wagh SR, MAYEE RV. Hepatoprotective activity of livergen, a polyherbal formulation against carbon tetrachloride induced hepatotoxicity in rats. Int J Pharma Pharmac Sci. 2011; 3: 228-31.

Avijeet, J, Manish S, Lokesh D, Anurekha J, Rout SP, Gupta VB, Krishna Kl. Antioxidant and hepatoprotective activity of ethanolic and aqueous extract of Momordica dioica Roxb. leaves. J Ethnopharmacol. 2008; 115: 61-66.

Awaad AS, Maitland DJ, Soliman GA. Hepatoprotective activity of Schouwia thebica webb. Bioorg Med Chem Lett. 2006; 16: 4624-28.

Babalola O, Ojo OE, Oloyede, FA. Hepatoprotective activity of aqueous extract of the leaves of Hyptis suaveolens on acetaminophen-induced hepatotoxicity in rabbits. Res J Chem Sci. 2011; 1: 85-88.

Babita MH, Chhaya G, Goldee P. Hepatoprotective activity of Rubia cordifolia. Pharmacologyonline. 2007; 3: 73-79.

Bag AK, Mumtaz SMF. Hepatoprotective and nephroprotec-tive activity of hydroalcoholic extract of Ipomoea staphylina leaves. Bangladesh J Pharmacol. 2013; 8: 263-68.

Balamurugan G, Muthusamy P. Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallai sharunnai) roots on carbon tetrachloride-treated rats. Bangladesh J Pharmacol. 2008; 3: 83-89.

Bhakta T, Banerjee S, Mandal SC, Maity TK, Saha BP, Pal M. Hepatoprotective activity of Cassia fistula leaf extract. Phytomed. 2001; 8: 220-24.

Chand N, Durrani FR, Ahmad S, Khan A. Immunomodulatory and hepatoprotective role of feed-added Berberis lycium in broiler chicks. J Sci Food Agric. 2011; 91: 1737-45.

Chandan BK, Saxena AK, Shukla S. Hepatoprotective potential of Aloe barbadensis Mill against carbontetrachloride induced hepatotoxicity. J Ethanopharmacol. 2007; 111: 560-66.

Dalia C, Nagalakshrni, P. Immunological alterations in murine model after inoculation of carbon tetrachloride. Antiseptic. 2000; 97: 297300.

Dey P, Saha MR, Sen A. Hepatotoxicity and the present herbal hepatoprotective scenario. Int J Green Pharm. 2013; 7: 265-73.

Dhanaraj TS, Gowthami R, Rajlakshmi S, Murugaiah K. Antihepatotoxicity of Hygrophila auriculata on CCl4 induced hepatotoxicity in rats . Asian J Res Pharm Sci. 2012; 2: 140-42.

Donfack HJ, Kengap RT, Ngameni B, Chuisseu P, Tchana AN, Buonocore D, Ngadjui BT, Moundipa PF, Marzatico F. Ficus cordata Thunb (Moraceae) is a potential source of some hepatoprotective and antioxidant compounds. Pharmacologia 2011; 2: 137-45.

Etim OE, Farombi EO, Usoh IF, Akpan EJ. The protective effect of Aloe vera juice on lindane induced hepatotoxicity and genotoxicity. Pak J Pharm Sci. 2006; 19: 333-37.

Friday UO, Ifeanyi E, Emmanuel AI, Godwin C, Emeka J. Analgesic and hepatoprotective activity of methanoilc leaf extract of Ocimum gratissimum. Res J Med Plant. 2012; 6: 108-19.

Gani SM, John SA. Evalution of hepatoprotective effect of Nigella sativa L. Int J Pharma Pharmac Sci. 2013; 5: 12-19.

Garba HS, Sambo N, Bala U. The effect of the aqueous extract of Kohautia grandiflora on paracetamol induced liver damage in albino rats. Nigerian J Physiol Sci. 2009; 24: 1723.

Gressner OA. Chocolate shake and blueberry pie or why your liver would love it. J Gastroenterol Hepatol Res. 2012; 1: 171-95.

Gujrati V, Patel N, Rao VN, Nandakumar K, Gouda TS, Shalam MD, Kumar SM. Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats. Indian J Pharmacol. 2007; 39: 43-47.

Gupta AK, Chitme H, Dass SK, Misra N. Antioxidant activity of Chamomile recutita capitula methanolic extracts against CCl4-induced liver injury in rats. J Pharmacol Toxicol. 2006; 1: 101-07.

Haque R, Subhasish M, Sinha S, Modhurupa GR, Sinha D, Sunita. Hepatoprotective activity of Clerodendron inerme against paracetamol-induced hepatic injury in rats for pharmaceutical product. Int J Drug Dev Res. 2011; 3: 23-28.

Hegde K, Joshi AB. Hepatoprotective and antioxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats. Bangladesh J Pharmacol. 2010; 5: 73-76.

Huang B, Ban X, He J, Zeng H, Zhang P, Wang Y. Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica. J Ethnopharmacol. 2010; 131: 276-81.

Hussain L, Akash MSH, Tahir M, Rehman K, Ahmed KZ. Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014; 9: 322-27.

Ibrahim M, Khaja MN, Aara A, Khan AA, Habeeb MA, Devi YP, Narasu ML, Habibullah M. Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies. World J Gastroenterol. 2008; 14: 256671.

Ilyas N, Sadiq M, Jehangir A. Hepatoprotective effect of garlic (Allium sativum) and milk thistle (silymarin) in isoniazid induced hepatotoxicity in rats. Biomedica 2011; 27: 166 -70.

Iwalokun BA, Efedede BU, Alabi-Sofunde JA, Oduala T, Magbagbeola OA, Akinwande AI. Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice. J Med Food. 2006; 9: 524-30.

Jain A, Soni M, Deb L, Jain A, Rout SP, Gupta VB, Krishna KL. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J Ethnopharmacol. 2008; 115: 61-66.

Jamshidzadeh A, Fereidooni F, Salehi Z, Niknahad H. Hepatoprotective activity of Gundelia tourenfortii. J Ethnopharmacol. 2005; 101: 233-37.

Jose JK, Kuttan R. Hepatoprotective activity of Emblica officinalis and Chyavanprash. J Ethnopharmacol. 2000; 72: 129-35.

Joshi UP, Mishra SH. In vitro antioxidant and hepatoprotective activity of isolated compounds from Pistacia integerrima. Aus J Medical Herbalism. 2010; 22: 22-34.

Joshi V, Sutar P, Karigar A, Patil S, Gopalakrishna B, Sureban R. Screening of ethanolic extract of Stachytarpheta indica l. (vahl) leaves for hepatoprotective activity. Int J Res Ayurveda Pharm. 2010; 1: 174-79.

Kaleem M, Asif M, Ahmed QU, Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2006; 47: 670-75.

Kamat CD, Khandelwal KR, Bodhankar SL, Ambawade SD, Mhetre NA. Hepatoprotective activity of leaves of Feronia elephantum Correa (Rutaceae) against carbon tetrachloride-induced liver damage in rats. J Nat Remed. 2003; 3: 148-54.

Kanchana N, Sadiq AM. Hepatoprotective effect of Plumbago zeylanica on paracetamol induced liver toxicity in rats. Int J Pharm Pharmac Sci. 2011; 3: 32-39.

Khan MA, Khan J, Ullah S, Malik SA, Shafi M. Hepatoprotective effects of Berberis lycium, Galium aparine and Pistacia integerrima in carbon tetrachloride (CCl4)-treated rats. J Postgrad Med Inst. 2008; 22: 19-25.

Khan RA, Khan MA, Ahmed M, Sahreen S, Shah NA, Shah MS, Bokhari J, Rashid U, Ahmad B, Jan S. Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. BMC Comp Alternative Med. 2012; 12: 114-19.

Kharpate S, Vadnerkar G, Jain D, Jain S. Evaluation of hepatoprotective activity of ethanol extract of Ptrospermum acerifolium Ster leaves. Ind J Pharmac Sci. 2007; 69: 850-53.

Khatri A, Garg A, Agrawal SS. Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata. J Ethnopharmacol. 2009; 122: 1-5.

Kiran PM, Raju AV, Rao BG. Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. Asian Pac J Trop Biomed. 2012; 2: 352-56.

Kumar A, Lakshman K, Kumar PA, Viswantha GL, Veerapur VP, Thippeswamy BS, Manoj B. Hepatoprotective activity of methanol extract of Amaranthus caudatus Linn. against paracetamol-induced hepatic injury in rats. J Chinese Integrative Med. 2011; 9: 194-200.

Kumar B, Sandhar H, Prasher S, Tiwari P, Salhan M, Sharma P. A review of phytochemistry and pharmacology of flavonoids. Int Pharmaceut Sciencia. 2011; 1: 25-41.

Kumar SV, Mishra SH. Hepatoprotective effect of Baliospermum montanum (Willd) Muell.- Arg against thioacetamide induced toxicity. Int J Compreh Pharm. 2012; 9: 1-4.

Lahon K, Das K. Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in albino rats. Pharmacognosy Res. 2011; 3: 1318.

Maaz A, Bhatti ASA, Maryam S, Afzal S, Ahmad M, Gilani AN. Hepatoprotective evaluation of Butea monosperma against liver damage by paracetamol in rabbits. Special Edit Annals. 2010; 16: 1-5.

Maheswari C, Maryammal R, Venkatanarayanan R. Hepatoprotective activity of Orthosiphon stamineus on liver damage caused by paracetamol in rats. Jor J Bio Sci. 2008; 1: 105-08.

Malar V, Mettilda M. Hepatoprotective activity of Phyllanthus emblica against paracetamol induced hepatic damage in Wister albino rats. Afri J Basic Applied Sci. 2009; 1: 21-25.

Mallhi TH, Abbas K, Ali M, Qadir MI, Saleem M, Khan YH. Hepatoprotective activity of methanolic extract of Malva parviflora against paracetamol-induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014; 9: 342-46.

Manjunatha BK, Vidya SM. Hepatoprotective activity of Vitex trifolia against carbon tetrachloride-induced hepatic damage. Indian J Pharm Sci. 2008; 70: 24145.

Matsuda H, Ninomiya K, Morikawa T, Yasuda D, Yamaguchi I, Yoshikawa M. Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides. Bio Med Chem. 2009; 17: 7313-23.

Mohamed AF, Ali Hasan AG, Hamamy MI, Abdel-Sattar E. Antioxidant and hepatoprotective effects of Eucalyptus maculata. Med Sci Monit. 2005; 11: 426-31.

Nadeem M, Dangiya PC, Pasha KV, Imara M, Balani DK, Vohora SB. Hepatoprotective activity of Solanum nigrum fruits. Fitoterapia. 1997; 58: 245-54.

Nafiu MO, Akanji MA, Yakubu MT. Effect of aqueous extract of Cochlospermum planchonii Rhizome on some kidney and liver functional indicies of albino rats. Afr J Tradit Complement Altern Med. 2011; 8: 2226.

Nayak SS, Jain R, Sahoo AK. Hepatoprotective activity of Glycosmis pentaphylla against paracetamol induced hepatotoxicity in Swiss albino mice. Pharm Biol. 2011; 49: 111-17.

Oh H, Kim DH, Cho JH, Kim YC. Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. J Ethnopharmacol. 2004; 95: 421-24.

Okwuosa CN, Udeani TK, Umeifekwem JE, Conuba E, Anioke IE, Madubueze RE. Hepatoprotective effect of methanolic fruit extracts of Phoenix dactylifera (Arecaceae) on thioacetamide induced liver damage in rats. Am J Phytomed Clinl Ther. 2014; 2: 290-300.

Om FR, Kumar R, Mani T, Niyas MK, Kumar SB,Phaneendra P, Surendra B. Hepatoprotective activity of Asparagus racemosus root on liver damage caused by paracetamol in rats. Indian J Novel Drug Delivery. 2011; 3: 112-17.

Ozbek H, U?ra? S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A. Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia. 2003; 74: 317-19.

Pari L, Kumar NA. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J Med Food. 2002; 5: 171-77.

Prabhakaran M, Rangasamy DT. Protective effect of Hemidesmus indicus against rifampicin and isoniazid induced hepatotoxicity in rats. Fitoterapia. 2000; 71: 55-59.

Pramyothin P, Chirdchupunsare H, Rungsipipat A, Chaichantipyuth C. Hepatoprotective activity of Thunbergia laurifolia Linn extract in rats treated with ethanol: In vitro and in vivo studies. J Ethnopharmacol. 2005; 102: 408-11.

Priya V, Niveda S, Pratiksha G, Gayathri R. A review of hepatoprotective natural products. Recent Res Sci Tech. 2010; 2: 49-52.

Qadir MI, Murad MSA, Ali M, Saleem M, Farooqi AA. Hepatoprotective effect of leaves of aqueous ethanol extract of Cestrum nocturnum against paracetamol-induced hepatotoxicity. Bangladesh J Pharmacol. 2014; 9: 167-70.

Qadir MI, Ali M, Ali M, Saleem M, Hanif M. Hepatoprotective activity of aqueous methanolic extract of Viola odorata against paracetamol-induced liver injury in mice. Bangladesh J Pharmacol. 2014; 9: 198-02.

Qureshi NN, Kuchekar BS, Logade NA, Haleem MA. Antioxidant and hepatoprotective activity of Cordia macleodii leaves. Saudi Pharm J. 2009; 17: 299-302.

Rajendran R, Hemalatha S, Akasakalai K, MadhuKrishna CH, Sohil B, Sundaram M. Hepatoprotective activity of Mimosa pudica leaves against carbon tetrachloride induced toxicity. J Nat Prod. 2009; 2: 116-22.

Raju K, Anbuganapathi G, Gokulakrishnan V, Rajkapoor B, Jayakar B, Manian S. Effect of dried fruits of Solanum nigrum LINN against CCl4-induced hepatic damage in rats. Biol Pharm Bull. 2003; 26: 1618-19.

Ramadan SI, Shalaby MA, Afifi N, El-Banna HA. Hepatoprotective and antioxidant effects of Silybum marianum plant in rats. Int J Agro Veter Med Sci. 2011; 5: 541-47.

Rani M, Emmanuel S, Sreekanth MR, Ignacimuthu S. Evaluation of in vivo antioxidant and hepatoprotective activity of Cassia occidentalis Linn. against paracetamol­induced liver toxicity in rats. Int J Pharm Pharmac Sci. 2010; 2: 67-70.

Rao BG, Raju NJ. Investigation of hepatoprotective activity of Spondias pinnata. Int J Pharma Sci Res. 2010; 1: 193-98.

Ravi V, Patel SS, Verma NK, Dutta D, Saleem TS. Hepatoprotective activity of Bombax ceiba Linn against isoniazid and rifampicin-induced toxicity in experimental rats. Int J Applied Res Nat Prod. 2010; 3: 19-26.

Ravikumar V, Shivashangari KS, Devaki T. Hepatoprotective activity of Tridax procumbens against d-galactosamine/lipopolysaccharide-induced hepatitis in rats. J Ethnopharmacol. 2005; 101: 55-60.

Rawat AK, Mehrotra S, Tripathi SC, Shome U. Hepatoprotective activity of Boerhaavia diffusa L. roots- A popular Indian ethnomedicine. J Ethnopharmacol. 1997; 56: 61-66.

Rehman JU, Saqib NU, Akhtar N, Jamshaid M, Asif HM, Sultana S, Rehman RU. Hepatoprotective activity of aqueous-methanolic extract of Suaeda fruticosa in paracetamol-induced hepatotoxicity in rabbits. Bangladesh J Pharmacol. 2013; 8: 378-81.

Saboo SS, Tapadiya G, Farooqui IA, Khadabadi SS. Free radical scavenging, in vivo antioxidant and hepatoprotective activity of folk medicine Trichodesma sedgwickianum. Bangladesh J Pharmacol. 2013; 8: 58-64.

Sahreen S, Muhammad RK, Rahmat AK.. Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. BMC Complem Altern Med. 2011; 11: 48-56.

Sadeque MZ, Begum ZA. Protective effect of dried fruits of Carica papaya on hepatotoxicity in rat. Bangladesh J Pharmacol. 2010; 5: 48-50.

Saleem M, Ahmed B, Qadir MI, Rafiq M, Ahmad M, Ahmad B. Hepatoprotective effect of Chenopodium murale in mice. Bangladesh J Pharmacol. 2014; 9: 124-28.

Saleem M, Ahmed B, Karim M, Ahmed S, Ahmad M, Qadir MI, Syed NIH. Hepatoprotective effect of aqeous methanolic extract of Rumex dentatus in paracetamol induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014; 9: 284-89.

Saleem M, Chetty M, Ramkanth S, Rajan V, Kumar MK, Gauthaman K. Hepatoprotective herbs: A review. Int. J. Res. Pharm. Sci. 2010; 1: 1-5.

Selvam, NT, Yathi K, Kumar S, Saraswathy V, Venugopalan T, Jaya N. Hepatoprotective activity of methanolic extract of Cinnamomum tamala (Nees) against paracetamol intoxicated Swiss albino mice. Int J Pharma World Res. 2010; 2: 2-7.

Setty SR, Quereshi AA, Swamy V, Patil T, Prakash T, Prabhu K, Gouda V. Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia. 2007; 78: 45154.

Shah VN, Deval K. Hepatoprotective activity of leaves of Parkinsonia aculeata Linn against paracetamol induced hepatotoxicity in rats. Int J Pharma. 2011; 1: 59-63.

Sharma SK, Suman N, Vasudeva N. Hepatoprotective activity of Vitis vinifera root extract against carbon tetrachloride-induced liver damage in rats. Acta Pol Pharm. 2012; 69: 933-37.

Singh B, Saxena AK, Chandan BK, Anand KK, Suri OP, Suri KA, Satti NH. Hepatoprotective activity of verbenalin on experimental liver damage in rodents. Fitoterapia. 1998; 58: 135-40.

Singh D, Gupta RS. Hepatoprotective activity of methanol extract of Tecomella undulata against alcohol and paracetamol induced hepatotoxicity in rats. Life Sci Med Res. 2011; 26: 1-6.

Singh D, Mehta S. Hepatoprotective activity of Sarcostemma brevistigma against carbon tetrachloride-induced hepatic damage in rats. Curr Sci. 2003; 84; 22-27.

Singh S, Mehta A, Mehta P. Hepatoprotective activity of Cajanus cajan against carbon tetrachloride induced liver damage. Int J Pharm Pharmac Sci. 2011; 3: 1-7.

Srirama R, Deepak HB, Senthilkumar U, Ravikanth G, Gurumurthy BR, Shivanna MB, Chandrasekaran CV, Agarwal A, Shaanker RU. Hepatoprotective activity of Indian Phyllanthus. Pharm Biol. 2012; 50: 948-53.

Srivastava A, Shivanandappa T. Hepatoprotective effect of the aqueous extract of the roots of Decalepis hamiltonii against ethanol-induced oxidative stress in rats. Hepatology Res. 2006; 35: 26775.

Sunilson J, Muthappan M, Das A, Suraj R, Varatharajan R, Promwichit P. Hepatoprotective activity of Coccinia grandis leaves against carbon tetrachloride induced hepatic injury in rats. Int J Pharmacol. 2009; 5: 222-27.

Sumitha P, Thirunalasundari T. Hepatoprotective activity of Aegle marmelos in CCl4 induced toxicity: An in vivo study. J Phyto. 2011; 3: 5-9.

Tabassum N, Agrawal S. Hepatoprotective activity of Eclipta alba hassk. against paracetamol induced hepatocellular damage in mice. Experimental Med. 2004; 11: 278-80.

Tabassum N, Chattervedi S, Aggrawal SS, Ahmed N. Hepatoprotective studies on paracetamol induced liver cell damage in Albino mice. JK-Practitioner. 2005; 12: 211-12.

Tasduq SA, Singh K, Satti NK, Gupta DK, Suri KA, Johri RK. Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Hum Exp Toxicol. 2006; 25: 111-18.

Thakare SP, Jain HN, Patil SD, Upadhyay UM. Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats. Bangladesh J Pharmacol. 2009; 4: 126-30.

Tortora GJ, Grabowski SR. The digestive system (liver and gallbladder): Principles of anatomy and physiology. New York, Harper Collins College Publishers, 2002; 792-95.

Tsai JC, Peng WH, Chiu TH, Huang SC, Huang TH, Lai SC, Lai ZR, Lee CY. Hepatoprotective effect of Scoparia dulcis on carbon tetrachloride induced acute liver injury in mice. Am J Chin Med. 2010; 38: 761-75.

Turel I, Özbek H, Erten R, Oner OC, Cengiz N, Yilmaz O. Hepatoprotective and anti-inflammatory activities of Plantago major L. J Pharmacol. 2009; 41: 12024.

Valan MF, Brittob AJ, Venkataramanc R A brief review: Phytoconstituents with hepatoprotective activity. Int J Chem Sci 2010; 8: 1421-32.

Verma N, Khosa RL. Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats. Indian J Biochem Biophys. 2010; 47: 124-27.

Vertichelvan T, Jegadeesan M, Senthil Palaniappan S. Diuretic and anti-inflammatory activities of Aerva lanata in rats. Indian J Pharm Sci. 2000; 62: 300-02.

Vonk RJ, Scholtens E, Keulemans GT, Meijer DK. Choleresis and hepatic transport mechanisms. IV. Influence of bile salt choleresis on the hepatic transport of the organic cations, D-tubocurarine and N4-acetyl procainamide ethobromide. Naunyn Schmiedebergs Arch Pharmacol. 1978; 302: 1-9.

Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y. The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. 2009; 126: 487-91.

Wang N, Li P, Wang Y, Peng W, Wu Z, Tan S, Liang S, Shen X, Su W. Hepatoprotective effect of Hypericum japonicum extract and its fractions. J Ethnopharmacol. 2008; 116: 1-6.

Ward FM, Daly MJ. Hepatic disease. In: Clinical pharmacy and therapeutics (Walker R, Edwards C. (eds.). New York, Churchill Livingstone, 1999, pp 195-212.

Wu Y, Yang L, Wang F, Wu X, Zhou C, Shi S, Mo J, Zhao Y. Hepatoprotective and antioxidative effects of total phenolics from Laggera pterodonta on chemical-induced injury in primary cultured neonatal rat hepatocytes. Food Chem Toxicol. 2007; 45: 1349-55.

Yasmin S, Kashmiri AM, Anwar K. Screening of aerial parts of Abutilon bidentatum for hepatoprotective activity in rabbits. J Med Plants Res. 2011; 5: 349-53.

Yen FL, Wu TH, Lin LT, Lin CC. Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats. J Ethnopharmacol. 2007; 111: 123-28.

Yen MH, Weng TC, Liu SY, Chai CY, Lin CC. The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats. Biol Pharm Bull. 2005; 28: 442-48.

Zeashan HA, Amresh GA, Satyawan SB, Venkateswara C. Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food and Chem Toxicol. 2008; 46: 3417-21.

Zhou D, Ruan J, Cai Y, Xiong Z, Fu W, Wei A. Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching. J Ethnopharmacol. 2010; 27: 232-37.

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Published

2014-10-19

How to Cite

Saleem, M., and F. Naseer. “Medicinal Plants in the Protection and Treatment of Liver Diseases”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 511-26, doi:10.3329/bjp.v9i4.20648.

Issue

Vol. 9 No. 4 (2014)

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Mini Review

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