In vitro antimicrobial evaluation of pyrazolone derivatives

Authors

  • Leile Rahimi Ahar Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran
  • Moayad Hossaini Sadr Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran
  • Karim Zare Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran
  • Samad Motameni Tabatabaei Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran

DOI:

https://doi.org/10.3329/bjp.v10i1.21166

Keywords:

Antimicrobial, Pyrazolone

Abstract

In this investigation, unsubstituted pyrazolin-3(5)-ones (MePzO= 3-methyl-5-pyrazolone, PrPzO= 3-propyl-5-pyrazolone and PhPzO= 3-phenyl-5-pyrazolone) have been synthesized. The synthesized compounds were also screened for their antibacterial activity against some Gram-positive and Gram-negative bacteria using agar well diffusion method. The compounds with different concentrations were prepared and the activity was determined by measuring the diameter of the inhibition zone (in mm). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the compounds were determined against six bacteria. The antibacterial activities were influenced functional groups (methyl, propyl and phenyl). PhPzO exhibited the strongest activity (MIC, 0.625 mg/mL; MBC, 2.5 mg/mL) against Bacillus subtilis.

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Published

2015-02-22

How to Cite

Ahar, L. R., M. H. Sadr, K. Zare, and S. M. Tabatabaei. “In Vitro Antimicrobial Evaluation of Pyrazolone Derivatives”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Feb. 2015, pp. 143-7, doi:10.3329/bjp.v10i1.21166.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

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