Extract of Brassica rapa suppresses ovalbumin-induced asthma by down-regulating NF-kappaB and p38 MAPK activity

Authors

  • Yun-Lei Dai Department of Pediatrics, The First Affiliated Hospital of Henan University of TCM, Zhengzhou 450000
  • Gui-Lian Shao Department of Pediatrics, Weihai Meternal and Child Health Hospital, Weihai 264200
  • Fang Wang Department of Pediatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007

DOI:

https://doi.org/10.3329/bjp.v10i1.21214

Keywords:

Asthma, Brassica rapa chinensis, NF-?B, p38MAPK, Th2 cytokines

Abstract

Asthma is one of the most common chronic inflammatory diseases characterized by airway infiltration of inflammatory cells inducing hyper-responsiveness. Due to the inefficacy of currently used drugs to definitely cure asthma, there is an insistent need for identification of novel therapies. In the present research, efficiency of Brassica rapa extract in asthma-induced mouse model was investigated. Asthma was induced in mice by ovalbumin induction. The extract (125-500 mg/kg) effectively reduced ovalbumin-specific IgE in serum and levels of interleukins (IL): IL-4, IL-5 and IL-13 in bronchoalveolar lavage fluid (BALF). B. rapa extract inhibited inflammatory cell infiltration in BALF and also improved lung compliance and airway resistance. The extract caused marked reduction in the expression levels of phosphorylated ERK, p38, I?B-? and NF-?B, however dose-dependent activation of JNK was observed. The extract of B. rapa thus was effective in suppressing ovalbumin-induced asthma.

 

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Published

2015-02-14

How to Cite

Dai, Y.-L., G.-L. Shao, and F. Wang. “Extract of Brassica Rapa Suppresses Ovalbumin-Induced Asthma by down-Regulating NF-KappaB and p38 MAPK Activity”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Feb. 2015, pp. 106-14, doi:10.3329/bjp.v10i1.21214.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

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