Sequential treatment with ursolic acid chlorophenyl triazole followed by 5-fluorouracil shows synergistic activity in small cell lung cancer cells

Authors

  • Rui-Xia Zhu Department of Oncology, Zaozhuang Mining Group Central Hospital, Zaozhuang, 277800
  • Lei Zhao Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011
  • Yu-Kun Zhang Department of Thoracic Surgery, Taian Central Hospital, Taian, 271000
  • Peng Luo Shanghai Topgen Biopharm Co., Ltd, Shanghai 200 000
  • Si-Hai Liu Department of Oncology, Zaozhuang Mining Group Central Hospital, Zaozhuang, 277800
  • Jin-Guang Wang Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011

DOI:

https://doi.org/10.3329/bjp.v10i1.21641

Keywords:

Apoptosis, Cytotoxic, 5-Fluorouracil, Neoplasm, Synergistic

Abstract

Combination therapy has prolonged the survival of patients with small cell lung cancer (SCLC), an aggressive neoplasm characterized by a high rate of metastasis. In the present study the effect of sequential treatment of ursolic acid chlorophenyl triazole (UACT) followed by 5-fluorouracil (5-FU) on human small cell lung cancer cells was investigated. The results revealed a synergistic effect of the sequential treatment with UACT and 5-FUcombination on cytotoxic activities, NF-kB protein activation, repression of TNF-induced NF-kB-dependent reporter gene expression, and TNF-induced COX-2, MMP-9 and Cyclin D1 activation in H209 cells. The synergism in apoptotic cell death was observed in H209, H69, 87-5,and Lu135 cells. The synergistic effect of UACT and 5-FU was observed at a concentration of 50 nM of UACT and 20 µM of 5-FU. These results indicate that UACT and 5-FU combination can be a promising chemotherapeutic regimen in the treatment of SCLC.

Downloads

Download data is not yet available.
Abstract
354
Download
148 Read
194

Downloads

Additional Files

Published

2015-03-09

How to Cite

Zhu, R.-X., L. Zhao, Y.-K. Zhang, P. Luo, S.-H. Liu, and J.-G. Wang. “Sequential Treatment With Ursolic Acid Chlorophenyl Triazole Followed by 5-Fluorouracil Shows Synergistic Activity in Small Cell Lung Cancer Cells”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Mar. 2015, pp. 197-04, doi:10.3329/bjp.v10i1.21641.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).