Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

Authors

  • Meng Hang Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Fan Zhao Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Shu-Bo Chen Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Qing Sun Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Chun-Xiao Zhang Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China

DOI:

https://doi.org/10.3329/bjp.v10i2.21739

Keywords:

Epithelial-Mesenchymal Transition, Kaempferol, Non-small cell lung cancer

Abstract

The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.

Downloads

Download data is not yet available.
Abstract
323
Download
286 Read
161

Downloads

Additional Files

Published

2015-04-01

How to Cite

Hang, M., F. Zhao, S.-B. Chen, Q. Sun, and C.-X. Zhang. “Kaempferol Modulates the Metastasis of Human Non-Small Cell Lung Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition”. Bangladesh Journal of Pharmacology, vol. 10, no. 2, Apr. 2015, pp. 267-70, doi:10.3329/bjp.v10i2.21739.

Issue

Vol. 10 No. 2 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).