In vitro anticancer potential and GC-MS analysis of Drimia nagarjunae, an endangered medicinal plant

Authors

  • Narendranath Alluri Department of Biotechnology, Center for Post Graduate Studies, Jain University, Jayanagar, Bangalore, 560 011, Karnataka
  • Mala Majumdar Department of Biotechnology, Center for Post Graduate Studies, Jain University, Jayanagar, Bangalore, 560 011, Karnataka

DOI:

https://doi.org/10.3329/bjp.v10i2.21909

Keywords:

Anticancer, Drimia nagarjunae, HCC cell line, GC-MS.

Abstract

The aim of the present study was to investigate the anticancer activity of Drimia nagarjunae (Liliaceae) extracts against Colo205 human colon cancer cell lines by SRB assay for the first time. The bulbs and leaves of the plant were sequentially extracted using solvents with increasing polarities (hexane> chloroform>ethyl acetate>methanol>water). Ethyl acetate and chloroform bulb extracts showed potent anticancer activity compared to standard, adriamycin. Both the extracts exhibited total growth inhibition of cell at 20.1 µg/mL and 32.1 µg/mL whereas adriamycin shown 33.1 µg/mL and 50% lethal concentration was found to be 61.5 µg/mL and >80 µg/mL respectively. The active extracts were subjected to GC-MS analysis for identification of phytocompounds and it showed seven and ten major compounds respectively. Therefore, the present study demonstrated that D. nagarjunae can be a promising candidate as an anticancer agent.

Downloads

Download data is not yet available.
Abstract
471
Download
419 Read
307

Author Biography

Mala Majumdar, Department of Biotechnology, Center for Post Graduate Studies, Jain University, Jayanagar, Bangalore, 560 011, Karnataka

Associate Professor

Downloads

Additional Files

Published

2015-04-07

How to Cite

Alluri, N., and M. Majumdar. “In Vitro Anticancer Potential and GC-MS Analysis of Drimia Nagarjunae, an Endangered Medicinal Plant”. Bangladesh Journal of Pharmacology, vol. 10, no. 2, Apr. 2015, pp. 303-7, doi:10.3329/bjp.v10i2.21909.

Issue

Vol. 10 No. 2 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).