Preliminary phytochemical screening and evaluation of hypoglycemic properties of the root extract of Uveria chamae

Authors

  • Emordi Jonathan Emeka Department of Pharmacology and Therapeutics College of Medicine, Ambrose Ali University Ekpoma, Nigeria
  • Agbaje Esther Oluwatoyin Department of Pharmacology, Therapeutics and toxicology, College of Medicine of the University of Lagos, Nigeria
  • Oreagba Ibrahim Adekunle Department of Pharmacology, Therapeutics and toxicology, College of Medicine of the University of Lagos, Nigeria
  • Iribhogbe Osede Ignis Department of Pharmacology and Therapeutics College of Medicine, Ambrose Ali University Ekpoma, Nigeria

DOI:

https://doi.org/10.3329/bjp.v10i2.22287

Keywords:

Diabetes mellitus, Hypoglycemia, Uveria chamae

Abstract

The purpose of this study is to evaluate the hypoglycaemic properties and preliminary phytochemical screening of Uveria chamae. The hypoglycaemic properties of Uveria chamae was assessed on normoglycaemic rat that received single dose of the extract at 250 and 500 mg/kg body weight and blood glucose levels estimated at 2, 4, and 6 hours (single dose study). The hypoglycaemic property of the extract was also evaluated in normoglycemic rats by oral glucose tolerance test. Phytochemical screening of the extract for the presence of secondary metabolites was performed with standard methods. The extract showed a significant (p<0.05) reduction in blood glucose levels at 2h and 6h compared to control.  The oral glucose tolerance test  result also showed a significant decrease (p<0.05) in blood glucose levels . The study showed that the extract, Uveria chamae has hypoglycaemic properties which may be accounted for by the presence of the phytochemicals.

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Author Biography

Emordi Jonathan Emeka, Department of Pharmacology and Therapeutics College of Medicine, Ambrose Ali University Ekpoma, Nigeria

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Additional Files

Published

2015-04-11

How to Cite

Emeka, E. J., A. E. Oluwatoyin, O. I. Adekunle, and I. O. Ignis. “Preliminary Phytochemical Screening and Evaluation of Hypoglycemic Properties of the Root Extract of Uveria Chamae”. Bangladesh Journal of Pharmacology, vol. 10, no. 2, Apr. 2015, pp. 326-31, doi:10.3329/bjp.v10i2.22287.

Issue

Vol. 10 No. 2 (2015)

Section

Research Articles

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