Evaluation of antileishmanial activity of plants used in Indian traditional medicine

Authors

  • Arushdeep Sidana Molecular and Immuno-parasitology Laboratory, Faculty of Biotechnology, Shoolini University, Solan, H.P., India
  • Umar Farooq Molecular and Immuno-parasitology Laboratory, Faculty of Biotechnology, Shoolini University, Solan, H.P., India

DOI:

https://doi.org/10.3329/bjp.v10i2.22674

Keywords:

Acorus calamus, Alstonia scholaris, Antileishmanial, Berberis aristata, Leishmania donovani, Traditional medicine

Abstract

The present study was aimed at in vitro antileishmanial screening of ten plants used in the traditional medicine in India. MTT method was used to evaluate the cell death after application of 100, 250, 350 and 500 ?g/mL of the methanolic extracts followed by incubation for 24 hours at 25°C. Methanolic leaf extracts of Acorus calamus, Alstonia scholaris and Berberis aristata showed significant antileishmanial activity at a concentration of 500 µg/ml. In order to identify the antileishmanial compounds present in the active extracts of the screened plants, an LC-MS analysis of the tested extracts was carried out. The active extracts revealed the presence of some natural products with known antileishmanial activity along with other compounds. The present study suggests that the active plant extracts may be processed to isolate the compounds that may further be screened for their antileishmanial potential.

Downloads

Download data is not yet available.
Abstract
325
Download
239 Read
175

Downloads

Additional Files

Published

2015-05-14

How to Cite

Sidana, A., and U. Farooq. “Evaluation of Antileishmanial Activity of Plants Used in Indian Traditional Medicine”. Bangladesh Journal of Pharmacology, vol. 10, no. 2, May 2015, pp. 423-6, doi:10.3329/bjp.v10i2.22674.

Issue

Vol. 10 No. 2 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).