Phytochemical screening and diuretic activity of Euphorbia granulata

Authors

DOI:

https://doi.org/10.3329/bjp.v10i3.22844

Keywords:

Diuretic, Euphorbia granulata

Abstract

The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of Euphorbia granulate in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The three doses of extract (30, 50 and 100 mg/kg) were given to rats (i.p) in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. The extract induced diuretic effects and induced electrolytes excretion in a dose-dependent manner when compared with control. The extract (100 and 50 mg/kg) significantly (p<0.01) increased the volume of urine in comparison to control group. Similarly, the excretion of potassium and sodium were also significantly (p<0.05) increased following extract administration. However, there was no significant change in the pH of urine samples of the extract-treated group compared with control. The result of this study thus offers support to the traditional folker use of this plant as a diuretic agent.

 

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Author Biographies

Hammad Saleem, Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan

Lecturer

M. Shoaib Ali Gill, Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan

Lecturer

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Published

2015-07-07

How to Cite

Saleem, Hammad, et al. “Phytochemical Screening and Diuretic Activity of Euphorbia Granulata”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 584-7, doi:10.3329/bjp.v10i3.22844.

Issue

Vol. 10 No. 3 (2015)

Section

Research Articles

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