Synthesis and biological evaluation of new hydrazide-Schiff bases

Authors

  • Asif Husain Department of Pharmaceutical Chemistry, Hamdard University, New Delhi 110062, India
  • Munendra M. Varshney College of Pharmaceutical Sciences, Raj Kumar Goel Institute of Technology, Ghaziabad, U.P. 201003, India
  • Versha Parcha Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India
  • Aftab Ahmad Health Information Technology Department, Jeddah Community College, King Abdul Aziz University, Jeddah 21589, Saudi Arabia
  • Shah Alam Khan Dept of Pharmacy, Oman Medical College, PO Box 620, PC 130, Muscat, Oman

DOI:

https://doi.org/10.3329/bjp.v10i3.23381

Keywords:

Anthelmintic, Antibacterial, Hydrazides, Schiff base

Abstract

A new series of N-({5-(substituted aryl)-furan-2-yl}-methylidene)-hydrazides were synthesized with a new class of Schiff bases derived from the reaction of substituted phenyl-1-ketohydrazide 2 or 2-(4-chloro-3-methylaryloxy) acetohydrazide 3 with different 5-(substituted aryl)-2-furfuraldehyde (1a-k) to yield substituted N-({5-(substituted aryl)-furan-2-yl}-methylidene)-hydrazides-Schiff bases (4a-f, 4g-k). The title compounds were subjected to in vitro antibacterial screening against Gram positive bacterial strains- S. aureus, B. cereus, E. faecalis and S. epidermidis, and Gram negative bacteria strains- E. coli, S. typhi, S. dysenteriae  and K. pneumoniae. The synthesized Schiff bases were also evaluated for their anthelmintic activity against two species of earthworms (Pheritima posthuma and Perionyx excavates). Some compounds have shown promising antibacterial and anthelmintic activities.

Downloads

Download data is not yet available.
Abstract
586
Download
339 Read
210

Author Biographies

Asif Husain, Department of Pharmaceutical Chemistry, Hamdard University, New Delhi 110062, India

Sr. Assistant Professor

Munendra M. Varshney, College of Pharmaceutical Sciences, Raj Kumar Goel Institute of Technology, Ghaziabad, U.P. 201003, India

Assistant Professor

Versha Parcha, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India

Professor

Aftab Ahmad, Health Information Technology Department, Jeddah Community College, King Abdul Aziz University, Jeddah 21589, Saudi Arabia

Assistant Professor

Shah Alam Khan, Dept of Pharmacy, Oman Medical College, PO Box 620, PC 130, Muscat, Oman

Associate Professor

Google Scholar Citation Index

Downloads

Additional Files

Published

2015-07-01

How to Cite

Husain, A., M. M. Varshney, V. Parcha, A. Ahmad, and S. A. Khan. “Synthesis and Biological Evaluation of New Hydrazide-Schiff Bases”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 555-61, doi:10.3329/bjp.v10i3.23381.

Issue

Vol. 10 No. 3 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).