Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway

Authors

  • Abdullah Aslan Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
  • Didem Boydak Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
  • Muhammed Ismail Can Department of Biotechnology and Molecular Biology, Aksaray University, Aksaray, Turkey
  • Tuncay Kuloglu Department of Histology and Embryology, Faculty of Medicine, Firat University, Elazig, Turkey

DOI:

https://doi.org/10.3329/bjp.v10i3.23486

Keywords:

Nigella sativa, Lung damage, Caspase-3, Caspase-9, erk, akt.

Abstract

The objective of this study was to examine whether Nigella sativa plays a protective role against the damage in the lung by administering carbon tetra-chloride (CCl4) to rats. Male Wistar albino (n=28, 8 weeks old) rats were divided into 4 groups: a) negative control: Normal water consuming group to which no CCl4 and N. sativa was administered; b) Positive control: Normal water consuming group to which no CCl4 was administered but N. sativa was administered; c) CCl4 Group: Normal water consuming and group to which CCl4 was administered (1.5 mL/kg, ip); d) N. sativa plus CCl4   group: CCl4 and N. sativa administered group (1.5 mL/kg, ip). Caspase-3, caspase -9, erk, akt protein syntheses were examined via Western blotting. Malondialdehyde determination in lung tissue was made using spectrophotometer. As a results, malondialdehyde amount was decreased in the CCl4 plus N. sativa group in comparison to CCl4 group whereas caspase-3, caspase-9 was increased and erk, akt had decreased. These results show that N. sativa protects the lung against oxidative damage.

 

Downloads

Download data is not yet available.
Abstract
325
Download
156 Read
161

Downloads

Additional Files

Published

2015-07-23

How to Cite

Aslan, A., D. Boydak, M. I. Can, and T. Kuloglu. “Nigella Sativa Improves the Carbon Tetrachloride-Induced Lung Damage in Rats through Repression of erk/Akt Pathway”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 654-9, doi:10.3329/bjp.v10i3.23486.

Issue

Vol. 10 No. 3 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).