GC-MS analysis, evaluation of phytochemicals, anti-oxidant, thrombolytic and anti-inflammatory activities of Exacum bicolor

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DOI:

https://doi.org/10.3329/bjp.v10i4.23610

Keywords:

Anti-inflammatory, Anti-oxidant, Exacum bicolor, GC-MS analysis, Thrombolytic activity

Abstract

The aim of the present study was to investigate the GC-MS analysis, phytochemical screening, anti-oxidant, thrombolytic and anti-inflammatory activities of methanol extract of leaves of Exacum bicolor. FTIR analysis confirmed the presence of alcohol, phenols, alkanes, aromatic compounds, aldehyde and ethers. GC-MS analysis revealed the presence of eight phyto-constituents. The total phenol, flavonoid and alkaloid contents were 18.0 ± 0.2 mg/GAE/g, 13.1 ± 0.4 mg QE/g and 108.0 ± 1.2 mg AE/g respectively. The DPPH assay exhibited potent anti-oxidant abilities with IC50 8.8 µg/mL. Significant thrombolytic activity was demonstrated by clot lysis method (45.1 ± 0.8%). The methanol extract showed significant membrane stabilization on human red blood cell with IC50 value of 37.4 µg/mL. There was a significant correlation (R2>0.98) with total phenolic content versus anti-oxidant and anti-inflammatory activity. The above results confirmed that E. bicolor could be a promising anti-oxidant, thrombolytic and anti-inflammatory agent.

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Author Biography

Mala Majumdar, Department of Biotechnology, Centre for Post Graduate Studies, Jain University, Bangalore, Karnataka 560011

Associate Professor

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Published

2015-09-21

How to Cite

Ashwini, A. M., L. Puttarudrappa, B. V. Ravi, and M. Majumdar. “GC-MS Analysis, Evaluation of Phytochemicals, Anti-Oxidant, Thrombolytic and Anti-Inflammatory Activities of Exacum Bicolor”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Sept. 2015, pp. 745-52, doi:10.3329/bjp.v10i4.23610.

Issue

Vol. 10 No. 4 (2015)

Section

Research Articles

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