Antidiarrheal and antispasmodic activities of Polygonum bistorta rhizomes are mediated predominantly through K+ channels activation

Authors

  • Muhammad Zeeshan Ali Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan
  • Malik Hassan Mehmood Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
  • Anwar Hassan Gilani Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800; Pakistan Council for Science and Technology, G-5/2, Islamabad, Pakistan

DOI:

https://doi.org/10.3329/bjp.v10i3.23714

Keywords:

Antidiarrheal, Antispasmodic, Ca channel antagonist, K channel activation, P. bistorta

Abstract

Polygonum bistorta is a popular medicinal herb used to treat diarrhea. This study provides pharmacological basis to its folk use in diarrhea using in vivo and in vitro assays. Administration of P. bistorta  rhizomes extract to mice offered protection against castor oil-induced diarrhea at 300-1,000 mg/kg and was found safe up to the dose of 5 g/kg. In isolated rabbit jejunum, the extract caused a dose-dependent relaxation of spontaneous and low K+ (25 mM)-induced contractions with weak effect against high K+ (80 mM). In tissues pretreated with glibenclamide or tetraethylammonium chloride (TEA), the relaxant effect of the extract was markedly inhibited by TEA only. While verapamil showed complete relaxation of spontaneous, low K+, low K+ with TEA and high K+-induced contractions. In guinea-pig ileum, mild atropine-sensitive effect was observed. This study indicates that P. bistorta possesses anti-diarrheal and antispasmodic activities mediated predominantly through K+-channels activation along with weak Ca++ antagonist effect.

 

Downloads

Download data is not yet available.

Author Biographies

Khalid Hussain Janbaz, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan

Professor

Google Scholar Citation Index

Anwar Hassan Gilani, Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800; Pakistan Council for Science and Technology, G-5/2, Islamabad, Pakistan

Professor

Chairman, Pakistan Council for Science and Technology
Google Scholar Citation Index

Downloads

Additional Files

Published

2015-07-14

How to Cite

Ali, Muhammad Zeeshan, et al. “Antidiarrheal and Antispasmodic Activities of Polygonum Bistorta Rhizomes Are Mediated Predominantly through K+ Channels Activation”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 627-34, doi:10.3329/bjp.v10i3.23714.

Issue

Vol. 10 No. 3 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).