Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

Authors

DOI:

https://doi.org/10.3329/bjp.v10i4.23732

Keywords:

Depression, Forced swimming test, Tail suspension test, Vitis vinifera

Abstract

The advantageous effects of Vitis vinifera juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. V. vinifera juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector. V. vinifera juice raised the levels of both serotonin (p<0.001) and noradrenalin (p<0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of V. vinifera juice against depressive disorders. Our results showed that V. vinifera juice could relieve depressive manifestations in the rodent model of depression.

Downloads

Download data is not yet available.
Abstract
334
Download
194 Read
125

Author Biographies

Muhammad Aslam, Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi

Research Scholar

Nuzhat Sultana, Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi

Assistant Professor

Downloads

Additional Files

Published

2015-09-22

How to Cite

Aslam, M., and N. Sultana. “Vitis Vinifera Juice Ameliorates Depression-Like Behavior in Mice by Modulating Biogenic Amine Neurotransmitters”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Sept. 2015, pp. 753-8, doi:10.3329/bjp.v10i4.23732.

Issue

Vol. 10 No. 4 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).