Cyanobacterial phycoerythrin purified from marine Lyngbya sp. induces apoptosis in lung carcinoma cells

Authors

  • Datta Madamwar BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Sardar Patel University,Vallabh Vidyanagar 388120, Anand, Gujarat, India
  • Avani Kaushal BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Sardar Patel University,Vallabh Vidyanagar 388120, Anand, Gujarat, India
  • Dipak K. Patel Ecotoxicology Lab, Jai Research Foundation, Vapi, Gujarat, India
  • Swati N. Desai Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India
  • Kapil Upadhyay Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India
  • Ranjitsinh Devkar Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India http://orcid.org/0000-0002-9863-7418

DOI:

https://doi.org/10.3329/bjp.v10i4.23896

Keywords:

Apoptosis, A549 cells, Cytotoxic, Lyngbya, C-Phycoerythrin

Abstract

Phycoerythrins from various cyanobacterial sources have been extensively studied globally for their therapeutic potentials. This study shows the apoptotic potential of cyanobacterial phycoerythrin isolated, purified and characterized from marine Lyngbya sp. A09DM on human lung carcinoma cells (A549 cell). Results indicated that purified cyanobacterial phycoerythrin accounted for a dose-dependent decrement in cell viability, mitochondrial membrane potential and an increment in lactate dehydrogenase release. Higher dose of cyanobacterial phycoerythrin caused loss of cell viability and nuclear condensation/fragmentation. Flow cytometry accounted for more number of cells in G0/G1 phase and an increase in total number of early apoptotic cells (39.5%). Overall, this study is the first to report on apoptotic property of cyanobacterial phycoerythrin from marine Lyngbya sp. A09DM against A549 human lung carcinoma cells and requires a detailed scrutiny to establish its anti-cancer potential.

Downloads

Download data is not yet available.
Abstract
367
Download
360 Read
179

Author Biography

Ranjitsinh Devkar, Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India

Assistant Professor

 

Downloads

Additional Files

Published

2015-09-25

How to Cite

Madamwar, D., A. Kaushal, D. K. Patel, S. N. Desai, K. Upadhyay, and R. Devkar. “Cyanobacterial Phycoerythrin Purified from Marine Lyngbya Sp. Induces Apoptosis in Lung Carcinoma Cells”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Sept. 2015, pp. 770-8, doi:10.3329/bjp.v10i4.23896.

Issue

Vol. 10 No. 4 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).