Cyanobacterial phycoerythrin purified from marine Lyngbya sp. induces apoptosis in lung carcinoma cells

Authors

  • Datta Madamwar BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Sardar Patel University,Vallabh Vidyanagar 388120, Anand, Gujarat, India
  • Avani Kaushal BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Sardar Patel University,Vallabh Vidyanagar 388120, Anand, Gujarat, India
  • Dipak K. Patel Ecotoxicology Lab, Jai Research Foundation, Vapi, Gujarat, India
  • Swati N. Desai Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India
  • Kapil Upadhyay Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India
  • Ranjitsinh Devkar Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India http://orcid.org/0000-0002-9863-7418

DOI:

https://doi.org/10.3329/bjp.v10i4.23896

Keywords:

Apoptosis, A549 cells, Cytotoxic, Lyngbya, C-Phycoerythrin

Abstract

Phycoerythrins from various cyanobacterial sources have been extensively studied globally for their therapeutic potentials. This study shows the apoptotic potential of cyanobacterial phycoerythrin isolated, purified and characterized from marine Lyngbya sp. A09DM on human lung carcinoma cells (A549 cell). Results indicated that purified cyanobacterial phycoerythrin accounted for a dose-dependent decrement in cell viability, mitochondrial membrane potential and an increment in lactate dehydrogenase release. Higher dose of cyanobacterial phycoerythrin caused loss of cell viability and nuclear condensation/fragmentation. Flow cytometry accounted for more number of cells in G0/G1 phase and an increase in total number of early apoptotic cells (39.5%). Overall, this study is the first to report on apoptotic property of cyanobacterial phycoerythrin from marine Lyngbya sp. A09DM against A549 human lung carcinoma cells and requires a detailed scrutiny to establish its anti-cancer potential.

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Author Biography

Ranjitsinh Devkar, Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India

Assistant Professor

 

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Published

2015-09-25

How to Cite

Madamwar, D., A. Kaushal, D. K. Patel, S. N. Desai, K. Upadhyay, and R. Devkar. “Cyanobacterial Phycoerythrin Purified from Marine Lyngbya Sp. Induces Apoptosis in Lung Carcinoma Cells”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Sept. 2015, pp. 770-8, doi:10.3329/bjp.v10i4.23896.

Issue

Vol. 10 No. 4 (2015)

Section

Research Articles

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