Effect of vitamin B12 supplementation on glycemic control in poorly controlled hyperhomocysteinemic type 2 diabetic patients

Authors

  • Yogendra Narayanrao Keche Department of Pharmacology, C. M. Medical College and Hospital, Kachandur, Durg, Chattisgarh 490024 http://orcid.org/0000-0003-0064-0019
  • Radha Yegnanarayan Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra
  • Shreepad Bhat Department of Medicine, Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra

DOI:

https://doi.org/10.3329/bjp.v11i1.24141

Keywords:

Glycemic control, Hyperhomocysteinemic, Type 2 diabetic, Vitamin B12 supplementation

Abstract

This study was conducted to observe the effect of vitamin B12 supplementation on glycemic control in poorly controlled hyperhomocysteinemic type 2 diabetic patients by measuring HbA1c levels at baseline and 4 weeks. Patient having serum homocysteine more than 15 µmol/L or vitamin B12 less than 223 pg/mL were enrolled in this study. One group received methylcobalamin 500 µg daily with their usual anti-diabetic therapy and the other group received only suitable anti-diabetic drug therapy. Methylcobalamin 500 µg was given daily for period of 4 weeks. Glycemic control was measured by levels of HbA1c, blood sugar at baseline and at 4 weeks. Serum homocysteine levels was reduced from 21.5 ± 2.6 to 15.4 ± 6.4 (p=0.04) with vitamin B12 supplementation at 4 weeks. At 4 weeks, HbA1c decreased from 9.9 ± 0.9 to 8.7 ± 0.5 (p<0.01) in vitamin B12 deficient patients after vitamin B12 supplementation. There is role of vitamin B12 in glycemic control in poorly controlled type 2 diabetic patients.

 

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Author Biographies

Yogendra Narayanrao Keche, Department of Pharmacology, C. M. Medical College and Hospital, Kachandur, Durg, Chattisgarh 490024

Associate Professor

Radha Yegnanarayan, Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra

Professor and Head, Department of Pharmacology

Shreepad Bhat, Department of Medicine, Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra

Professor and Head

References

Ambrosch A. Relation between homocysteinaemia and diabetic neuropathy in patients with type 2 diabetes mellitus. Diabetic Med. 2001; 18: 185-92.

Buysschaert M, Dramais A-S, Wallemacq PE, Hermans MP: Hyperhomocysteinemia in type 2 diabetes: Relationship to macroangiopathy, nephropathy, and insulin resistance. Diabetes Care. 2000; 23: 181622.

Barnard ND, Cohen J, Jenkins DJ, Turner-Mc Grievy G, Gloede L, Jaster B, Seidl K, Green AA, Talpers S. A low fat vegan diet improves glycaemic control and cardiovascular risk factors in randomized clinical trial in individuals with type 2 diabetes. Diabetes Care. 2006; 29: 1777-83.

Ebesunun MO, Obajobi EO. Elevated plasma homocysteine in type 2 diabetes mellitus: A risk factor for cardiovascular diseases. Pan African Med J. 2012; 12: 48.

Jager A, Kostense PJ, Nijpels G, Dekker JM, Heine RJ, Bouter LM, Donker AJM, Stehouwer CD. Serum homocysteine levels are associated with the development of (micro)albuminuria: The Hoorn Study. Arterioscler Thromb Vasc Biol. 2001; 21: 74-81.

Kibirige D, Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: Is routine screening and supplementation justified? J Diabetes Metabol Dis. 2013; 12: 17.

Klee GG. Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs vitamin B12 and folate. Clin Chem. 2000; 46: 1277-83.

Mahendran KB, Santha K, Santhoshkumar N, Desigan EG, Mohammad A. Serum homocysteine and lipid profile levels in type 2 diabetes mellitus patients. Int J Med Res Health Sci. 2013; 2: 200-05.

Obeid R. Metformin causing vitamin B12 deficiency: A guilty verdict without sufficient evidence. Diabetes Care. 2014; 37: e2223.

Ramachandran L, Negi NS, Gupta B. Prevalence of hyperhomocysteinaemia in type 2 diabetes mellitus and its correlation with its complications. J Indian Aca Clin Med. 2012; 13: 277-81.

Schnyder G. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after Percutaneous Coronary Intervention The Swiss Heart Study: A randomized controlled trial. JAMA. 2002; 288: 973-79.

Soinio M. High Homocysteine levels increase risk for heart attacks in people with type 2 diabetes mellitus. Ann Intern Med. 2004; 140: 1-31.

Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr. 2009; 60: 7176.

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Published

2015-12-17

How to Cite

Keche, Y. N., R. Yegnanarayan, and S. Bhat. “Effect of Vitamin B12 Supplementation on Glycemic Control in Poorly Controlled Hyperhomocysteinemic Type 2 Diabetic Patients”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Dec. 2015, pp. 50-53, doi:10.3329/bjp.v11i1.24141.

Issue

Vol. 11 No. 1 (2016)

Section

Clinical Trial

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