Protective effects of paeonol on cardiovascular complications in diabetes mellitus involves modulation of PI3K /Akt-GSK-3β signalling, regulation of protease-activated receptor-1 expressions and down-regulation of inflammatory mediators

Authors

  • Jun Li Department of Cardiology, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000
  • Ze-Qing Xu Department of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000
  • Ling Bao Department of Laboratory, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000
  • Zhi-Cao Li Department of Geriatrics, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000
  • Jia-Xiang Qu Department of Geriatrics, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000 http://orcid.org/0000-0002-8156-0784

DOI:

https://doi.org/10.3329/bjp.v10i4.24334

Keywords:

Cardiovascular, Diabetes mellitus, Inflammatory mediator, Paeonol, PI3K /Akt-GSK-3? signaling, Protease-activated receptor-1 expression

Abstract

The present study was taken as an effort to assess the effects of paeonol on diabetic cardiomyopathy. Diabetes was induced in separate groups of Sprague-Dawley rats using streptozotocin. Treatment group animals received paeonol (50, 100 or 200 mg/kg body weight/day; orally) 5 weeks after streptozotocin induction for 6 weeks. Paeonol strikingly reduced myocardial apoptosis and improved cardiac function and myocardial architecture. Serum levels of glucose, reactive oxygen species and inflammatory mediators (TNF-α, IL-6 and IL-1β) were significantly reduced with decreased accumulation of collagen in the cardiac tissue. Paeonol modulated p-Akt, glycogen synthase kinase-3β and glycogen synthase, while significantly down-regulated protease-activated receptor-1, caspase-3, TNF-α, NF-κB p65, and p-Iκ-Bα expressions. Paeonol effectively suppressed diabetic cardiomyopathy by improving myocardial function, regulating the inflammatory responses and Akt signalling.

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Published

2015-11-04

How to Cite

Li, J., Z.-Q. Xu, L. Bao, Z.-C. Li, and J.-X. Qu. “Protective Effects of Paeonol on Cardiovascular Complications in Diabetes Mellitus Involves Modulation of PI3K /Akt-GSK-3β Signalling, Regulation of Protease-Activated Receptor-1 Expressions and down-Regulation of Inflammatory Mediators”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Nov. 2015, pp. 903-16, doi:10.3329/bjp.v10i4.24334.

Issue

Vol. 10 No. 4 (2015)

Section

Research Articles

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