Phytochemical investigation, GC-MS analysis and in vitro antimicrobial activity of Coleus forskohlii

Authors

  • Krishnamoorthy Rajkumar PG and Research Department of Biotechnology, Sri Vinayaga College of Arts and Science, Ulundurpet 606107, Tamilnadu, India
  • Ramaswamy Malathi Research Department of Biotechnology, Bharathidasan University constituent College,Kurumbalur, Perambalur 621107, Tamilnadu, India

DOI:

https://doi.org/10.3329/bjp.v10i4.24406

Keywords:

Antimicrobial, Coleus forskohlii, GC-MS

Abstract

The aim of this study was to investigate the phytochemical constituents, gas chromatography-mass spectrometry (GC-MS) analysis and antimicrobial activity of Coleus forskohlii. The different solvents such as ethanol, chloroform, acetone and aqueous extracts were identified pharmacologically as important bioactive compounds and their antimicrobial properties were studied. In the phytochemical investigation almost all the ethanol extract of leaf, stem and root having secondary metabolites like alkaloids, flavonoids, tannins, saponins, terpenoids, and steroids. The active constituents of the ethanol extract of C. forskohlii root was studied by GC-MS analysis. According to the antimicrobial results ethanol extract of C. froshkolii root showed highest antibacterial activity compared with stem and leaf. The highest antimicrobial activity was observed against Klebsiella pneumonia (19 mm) and Candida albicans (16 mm) in ethanol extract of root. Among the above extracts of leaf, stem and root, ethanol extract of root having antimicrobial activities due to the presence of phytoconstituents.

Downloads

Download data is not yet available.
Abstract
452
Download
271 Read
228

Author Biographies

Krishnamoorthy Rajkumar, PG and Research Department of Biotechnology, Sri Vinayaga College of Arts and Science, Ulundurpet 606107, Tamilnadu, India

Assistant Professor

Ramaswamy Malathi, Research Department of Biotechnology, Bharathidasan University constituent College,Kurumbalur, Perambalur 621107, Tamilnadu, India

Assistant Professor

Downloads

Additional Files

Published

2015-11-05

How to Cite

Rajkumar, K., and R. Malathi. “Phytochemical Investigation, GC-MS Analysis and in Vitro Antimicrobial Activity of Coleus Forskohlii”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Nov. 2015, pp. 924-30, doi:10.3329/bjp.v10i4.24406.

Issue

Vol. 10 No. 4 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).