Assessment of dual inhibitory activity of epifriedelanol isolated from Cayratia trifolia against ovarian cancer
DOI:
https://doi.org/10.3329/bjp.v11i2.24933Keywords:
Cayratia trifolia, Epifriedelanol, Ovarian cancerAbstract
Cayratia trifolia is used as diuretic, in tumors, neuralgia and splenopathy. However, compounds depicting anti-ovarian cancer activities from this plant source have not yet been identified and structurally characterized till date. In the present study, X-ray structure of epifriedelanol, a bioactive compound, isolated from the ethanolic extract of the C. trifolia and its binding affinities against a few proteins (HER2, EGFR and CXCR4) that are reported to get overexpressed under ovarian cancer had been thoroughly studied by using molecular docking means. Binding affinities of the compound vis-à-vis that of carboplatin, a FDA approved drug to the ovarian cancer, to interact with the protein targets are quite impressive. The drug-likeness properties of the epifriedelanol and scope to develop the compound as a potent anti-ovarian cancer drug are discussed in this paper.
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References
Cremer D, Pople JA. Cremer Pople Analysis. J Am Chem Soc. 1975; 97: 1354-58.
Desai AG, Qazi GN, Ganju RK, Tamer M, Singh J, Saxena AK, Bedi YS, Taneja SC, Bhat HK. Medicinal plants and cancer chemoprevention. Curr Drug Metab. 2008; 9; 581-91.
Dhanamani M, Devi SL, Kannan S. Ethnomedicinal plants for cancer therapy: A review. Hygeia J D Med. 2011; 3: 1-10.
Dutta RK, Maharia RS. Anti-oxidant responses of some common medicinal plants grown in copper mining areas. Food Chem. 2012; 131: 25965.
Farrugia LJ. Win GX. J Appl Cryst. 2012; 45: 84954.
Fortes C, García-Vilas JA, Quesada AR, Medina MA. Evaluation of the anti-angiogenic potential of hydroxytyrosol and tyrosol, two bio-active phenolic compounds of extra virgin olive oil, in endothelial cell cultures. Food Chem. 2012; 134: 134-40.
Gupta J, Kumar D, Gupta A. Evaluation of gastric anti-ulcer activity of methanolic extract of Cayratia trifolia in experimental animals. Asian Pac J Trop Dis. 2012; 2: 99-102.
Jayson GC, Kohn EC, Kitchener HC, Ledermann JA. Ovarian cancer. Lancet 2014; 384: 137688.
Khan A, Khan RA, Ahmed M, Mushtaq N. In vitro anti-oxidant, anti-fungal and cytotoxic activity of methanolic extract of Calligonum polygonoides. Bangladesh J Pharmacol. 2015; 10: 316-20.
Kundu JK, Rouf ASS, Hossain N, Hasan CM, Rashid MA. Antitumor activity of epifriedelanol from Vitis trifolia. Fitoterapia 2000; 71: 577-79.
Li XH, Li C, Xiao ZQ. Proteomics for identifying mechanisms and biomarkers of drug resistance in cancer. J Proteomics. 2011; 74: 2642-49.
Perumal PC, Sophia D, Raj CA, Ragavendran P, Starlin T, Gopalakrishnan VK. In vitro antioxidant activities and HPTLC analysis of ethanolic extract of Cayratia trifolia (L.). Asian Pac J Trop Dis. 2012; 2: S952-56.
Perumal PC, Sowmya S, Pratibha P, Vidya B, Anusooriya P, Starlin T, Ravi S, Gopalakrishnan V.K. Isolation, structural characterization and in silico drug-like properties prediction of bioactive compound from ethanolic extract of Cayratia trifolia (L.). Pharmacog Res. 2015; 7: 121-25.
Perumal PC, Sowmya S, Pratibha P, Vidya B, Anusooriya P, Starlin T, Vasanth R, Sharmila DJS, Gopalakrishnan VK. Identification of novel PPAR? agonist from GC-MS analysis of ethanolic extract of Cayratia trifolia (L.): A computational molecular simulation studies. J Appl Pharm Sci. 2014; 4: 6-11.
Poornima K, Perumal PC, Gopalakrishnan VK. Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar albino rats. Biomed Res Int. 2014; 2014: 1-9.
Pratibha P, Sophia D, Perumal PC, Gopalakrishnan VK. In-silico docking analysis of Emilia sonchifolia (L.) dc. gas chromatography-mass spectroscopy derived terpenoid compounds against pancreatic cancer targets (AKT and BRCA2). World J Pharm Pharm Sci. 2014; 3: 1844-55.
Sharma B, Dhamija I, Kumar S, Chaudhary H. In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma. Bangladesh J Pharmacol. 2015; 10: 399-408.
Sheldrick GM. A short history of SHELX. Acta Cryst A. 2008; 64: 11222.
Singh S, Mann R, Sharma SK. Phytochemical analysis and pharmacognostical standardization of stem of Cayratia trifolia (Linn.) Domin. Int J Pharm Sci Res. 2012; 3: 4503-06.
Spek AL. Structure validation in chemical crystallography. Acta Cryst D. 2009; 65: 14855.
Srinivasan P, Perumal PC, Sudha A. Discovery of novel inhibitors for Nek6 protein through homology model assisted structure based virtual screening and molecular docking approaches. Sci World J. 2014; 2014: 1-9.
Starlin T, Ragavendran P, Raj CA, Perumal PC, Gopalakrishnan VK. Element and functional group analysis of Ichnocarpus frutescens R. Br. (Apocynaceae). Int J Pharm Pharm Sci. 2012; 4: 343-45.
Sultana N, Rahman MM. Ahmed S, Akter S, Haque MM, Parveen S, Moeiz SMI. Antimicrobial compounds from the rihzomes of Sansevieria hyacinthoides. Bangladesh J Sci Ind Res. 2011; 46: 329-32.
Tripathi SK, Singh SK, Singh P, Chellaperumal P, Reddy KK, Selvaraj C. Exploring the selectivity of a ligand complex with CDK2/CDK1: A molecular dynamics simulation approach. J Mol Recognit. 2012; 25: 504-12.
Yu J, Ma Y, Drisko J, Chen Q. Anti-tumor activities of Rauwolfia vomitoria extract and potentiation of carboplatin effects against ovarian cancer. Curr Ther Res. 2013; 75: 8-14.
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