Assessment of dual inhibitory activity of epifriedelanol isolated from Cayratia trifolia against ovarian cancer

Authors

  • Palanisamy Chella Perumal Cancer Biology and Medicinal Chemistry Research Unit, Department of Biochemistry and Bioinformatics, Karpagam University, Coimbatore 641-021, Tamil Nadu
  • Sundaram Sowmya Cancer Biology and Medicinal Chemistry Research Unit, Department of Biochemistry and Bioinformatics, Karpagam University, Coimbatore 641-021, Tamil Nadu
  • Devadasan Velmurugan UGC-BSR-Faculty CAS in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600-025
  • Thirunavukkarasu Sivaraman Structural Biology Lab, ASK, Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613-401, Tamil Nadu
  • Velliyur Kanniappan Gopalakrishnan Cancer Biology and Medicinal Chemistry Research Unit, Department of Biochemistry and Bioinformatics, Karpagam University, Coimbatore 641-021, Tamil Nadu http://orcid.org/0000-0003-2932-2874

DOI:

https://doi.org/10.3329/bjp.v11i2.24933

Keywords:

Cayratia trifolia, Epifriedelanol, Ovarian cancer

Abstract

Cayratia trifolia is used as diuretic, in tumors, neuralgia and splenopathy. However, compounds depicting anti-ovarian cancer activities from this plant source have not yet been identified and structurally characterized till date. In the present study, X-ray structure of epifriedelanol, a bioactive compound, isolated from the ethanolic extract of the C. trifolia and its binding affinities against a few proteins (HER2, EGFR and CXCR4) that are reported to get overexpressed under ovarian cancer had been thoroughly studied by using molecular docking means. Binding affinities of the compound vis-à-vis that of carboplatin, a FDA approved drug to the ovarian cancer, to interact with the protein targets are quite impressive. The drug-likeness properties of the epifriedelanol and scope to develop the compound as a potent anti-ovarian cancer drug are discussed in this paper.

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Author Biography

Velliyur Kanniappan Gopalakrishnan, Cancer Biology and Medicinal Chemistry Research Unit, Department of Biochemistry and Bioinformatics, Karpagam University, Coimbatore 641-021, Tamil Nadu

Professor

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Published

2016-05-11

How to Cite

Perumal, P. C., S. Sowmya, D. Velmurugan, T. Sivaraman, and V. K. Gopalakrishnan. “Assessment of Dual Inhibitory Activity of Epifriedelanol Isolated from Cayratia Trifolia Against Ovarian Cancer”. Bangladesh Journal of Pharmacology, vol. 11, no. 2, May 2016, pp. 545-51, doi:10.3329/bjp.v11i2.24933.

Issue

Vol. 11 No. 2 (2016)

Section

Research Articles

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