Anti-oxidant and anti-acetylcholinesterase activities of Zygophyllum album

Authors

  • Mouna Kchaou Laboratory of Chemistry of Natural Substances, Faculty of Sciences of Sfax, University of Sfax, Sfax 3000
  • Hichem Ben Salah Laboratory of Chemistry of Natural Substances, Faculty of Sciences of Sfax, University of Sfax, Sfax 3000 http://orcid.org/0000-0003-3012-2845
  • Rania Mhiri Laboratory of Chemistry of Natural Substances, Faculty of Sciences of Sfax, University of Sfax, Sfax 3000
  • Noureddine Allouche Laboratory of Chemistry of Natural Substances, Faculty of Sciences of Sfax, University of Sfax, Sfax 3000

DOI:

https://doi.org/10.3329/bjp.v11i1.25463

Keywords:

Anti-acetylcholinesterase, Anti-oxidant, Zygophyllum album

Abstract

The present study was carried out to explore the anti-acetylcholinesterase activity and anti-oxidant effect as well as content of phenolic compounds of various extracts from Zygophyllum album. It was observed that dichloromethane and ethanol extracts were endowed with a powerful anti-acetylcholinesterase activity with IC50 values of 40 and 58 µg/mL, respectively. These two extracts exhibited the highest DPPH radical scavenging activity (IC50=0.2 mg/mL), the highest total anti-oxidant capacity (185.2 and 222.4 mg vitamin E/mg extract, respectively), the highest reducing power effect, and the highest ?-carotene bleaching capacity. The findings showed that the extents of anti-acetylcholinesterase activity of Z. album extracts as well as their anti-oxidant capacity are in accordance with their phenolic contents. Hence, Z. album leaves would be useful against Alzheimer's disease.

Video Clip of Methodology:

Determination of flavonoids content:  2 min 50 sec   Full Screen   Alternate

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Published

2015-12-17

How to Cite

Kchaou, M., H. Ben Salah, R. Mhiri, and N. Allouche. “Anti-Oxidant and Anti-Acetylcholinesterase Activities of Zygophyllum Album”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Dec. 2015, pp. 54-62, doi:10.3329/bjp.v11i1.25463.

Issue

Vol. 11 No. 1 (2016)

Section

Research Articles

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