Intravenous caffeine versus intravenous ketorolac for the management of moderate to severe migraine headache

Authors

  • Alireza Baratloo Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran
  • Sara Arab Bafarani Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran
  • Mohammad Mehdi Forouzanfar Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran
  • Behrooz Hashemi Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran
  • Benjamin Wolkin Friedman Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
  • Ali Abdalvand Department of Emergency Medicine, University of Calgary, Calgary, AB

DOI:

https://doi.org/10.3329/bjp.v11i2.26333

Keywords:

Migraine Headache, Ketorolac, Caffeine, Pain Management, Emergency Department

Abstract

The aim of this study was to determine if intravenous caffeine is as effective as intravenous ketorolac for the treatment of moderate to severe migraine headaches. Eligible patients randomly received 60 mg caffeine citrate or 60 mg ketorolac infused intravenously. Their pain score were measured at baseline, one hour and two hours after infusion. Therapeutic success was defined as decreasing of at least 3 points on the pain score. In total 110 patients were enrolled (75.5% women). Therapeutic success after 60 min was achieved by 63.6% of patients in the caffeine and 70.1% of patients in the ketorolac group (p = 0.23). After 120 min, 87.3% of the caffeine group and 83.6% of the ketorolac group achieved therapeutic success (p = 0.49). In this multi-center, randomized double blind study, intravenous caffeine was as effective as intravenous ketorolac for first line abortive management of acute migraine.

 

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Published

2016-04-02

How to Cite

Baratloo, A., S. A. Bafarani, M. M. Forouzanfar, B. Hashemi, B. W. Friedman, and A. Abdalvand. “Intravenous Caffeine Versus Intravenous Ketorolac for the Management of Moderate to Severe Migraine Headache”. Bangladesh Journal of Pharmacology, vol. 11, no. 2, Apr. 2016, pp. 428-32, doi:10.3329/bjp.v11i2.26333.

Issue

Vol. 11 No. 2 (2016)

Section

Clinical Trial

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