Preparation and release characteristics study on the novel minocycline hydrochloride sustained-release capsule

Authors

  • Songfeng Zhao Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052
  • Xiao Zhang Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052
  • Xiaojian Zhang Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052
  • Xiuqin Shi Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052
  • Jun Li Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052
  • Quancheng Kan The Provincial Key Lab of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052
  • Shuoye Yang College of Bioengineering, Henan University of Technology, Zhengzhou

DOI:

https://doi.org/10.3329/bjp.v11iS1.26415

Keywords:

Minocycline, Sustained-release capsule

Abstract

In present study, a novel minocycline hydrochloride sustained-release capsule was prepared with the new extrusion-spheronization method. The in vitro release studies were performed using marketed sample as a reference and data were analyzed in terms of cumulative release amounts as a function of time. Results demonstrated that the developed analysis method was reliable and convenient for the quantification and dissolution study of minocycline hydrochloride. The release characteristics of different batches of preparations were quite similar with each other, similarity factors f2  of 12 batches were all within 50-100, and our developed sample was similar to reference preparation in release characteristics in vitro. The developed sustained-release preparation may be a promising alternative dosage form for treatment of related diseases.

 

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Published

2016-02-21

How to Cite

Zhao, S., X. Zhang, X. Zhang, X. Shi, J. Li, Q. Kan, and S. Yang. “Preparation and Release Characteristics Study on the Novel Minocycline Hydrochloride Sustained-Release Capsule”. Bangladesh Journal of Pharmacology, vol. 11, no. S1, Feb. 2016, pp. S36-S42, doi:10.3329/bjp.v11iS1.26415.

Issue

Vol. 11 (2016): Special Issue

Section

Research Articles

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