Anti-tumor effect of Huayu Jiedu formula on SGC-7901 cancer cell

Authors

  • Wei Zheng Nanjing University of Chinese Medicine, Nanjing, Jiangsu http://orcid.org/0000-0003-4667-1005
  • Zhang Junping Academy Institutes of Traditional Chinese Medicine, Zhengzhou, Henan
  • Zhang Aihua Academy Institutes of Traditional Chinese Medicine, Zhengzhou, Henan
  • Fan Junming Academy Institutes of Traditional Chinese Medicine, Zhengzhou, Henan
  • Wang Yanchun Henan Province People's Hospital, Zhengzhou, Henan
  • Liu Yanqing Yangzhou University, Yangzhou 225009

DOI:

https://doi.org/10.3329/bjp.v11i0.26689

Keywords:

Anti-tumor, Huayu Jiedu, SGC-7901 cancer cell

Abstract

In this study, we evaluated the effects of the extract of Huayu Jiedu (HYJD) formula on anti-tumor activity. It was found that HYJD treatment inhibited proliferation of seven cancer cell lines (IC50: 1.23-6.23 mg/mL). The gastric cancer cell line SGC-7901 was the most sensitive to HYJD. HYJD inhibited SGC-7901 cells proliferation in a dose- and time-dependant manner. More-over, HYJD significantly inhibited SGC-7901 cells adhesion, invasion and migration in a dose-dependent manner. qPCR results showed that HYJD treatment had no effect on PI3K, PDK1 and Akt mRNA expression. However, HYJD dramatically down-regulated Akt phosphorylation through inhibition of PDK1 kinase activity. Importantly, HYJD inhibited growth of tumor xenografts with no effect on body weight and spleen index. HYJD also significantly down-regulated Akt phosphorylation in tumor tissue. Taken together, this study demonstrated that HYJD exhibited an anti-tumor property, suggesting that HYJD may be a potential drug in the treatment of cancer.

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Published

2016-02-14

How to Cite

Zheng, W., Z. Junping, Z. Aihua, F. Junming, W. Yanchun, and L. Yanqing. “Anti-Tumor Effect of Huayu Jiedu Formula on SGC-7901 Cancer Cell”. Bangladesh Journal of Pharmacology, vol. 11, no. S1, Feb. 2016, pp. S8-S17, doi:10.3329/bjp.v11i0.26689.

Issue

Section

Research Articles