Effects of Curculigo orchioides total glucosides in mouse perimenopause model of related organization and organs morphology

Authors

  • Cao Shan Henan University of Traditional Chinese Medicine, Henan, 450008
  • Tian Shuo Henan University of Traditional Chinese Medicine, Henan, 450008
  • Bai Ming Henan University of Traditional Chinese Medicine, Henan, 450008
  • Liu Shaoyan Henan University of Traditional Chinese Medicine, Henan, 450008
  • Jia Jiaojiao Henan University of Traditional Chinese Medicine, Henan, 450008
  • Miao Mingsan Henan University of Traditional Chinese Medicine, Henan, 450008

DOI:

https://doi.org/10.3329/bjp.v11iS1.26948

Keywords:

Curculigo orchioides, Glucoside, Mouse, Perimenopause

Abstract

The purpose of this study was to examine the effects of Curculigo orchioides total glucosides in mouse perimenopause model. The castrated mice were treated with different doses of soybean isoflavone soft capsule, Gengnianan, C. rhizome total glycoside. Hypothalamus, thymus, spleen and uterus were collected and then fixed in 10% formaldehyde, HE staining, to observe the pathological changes of morphology. The results indicate that compared with the model group, soybean isoflavone soft capsule, gengnianan capsule and big, medium, small dose of C. rhizome total glycoside group could significantly improved the pathological changes in mouse uterus, hypothalamic, thickening of the thymic cortex and significantly increased the number of lymphocytes in the cortex, increased the volume of splenic nodule (p<0.01), in which the effect of large dose of C. orchioides total glycosides group was the best. In conclusion, C. orchioides total glucosides in mice caused by perimenopausal pathological changes of uterine, hypothalamus, spleen and other organs have good improvement effect.

 

Downloads

Download data is not yet available.
Abstract
258
Download
107 Read
84

Downloads

Additional Files

Published

2016-03-05

How to Cite

Shan, C., T. Shuo, B. Ming, L. Shaoyan, J. Jiaojiao, and M. Mingsan. “Effects of Curculigo Orchioides Total Glucosides in Mouse Perimenopause Model of Related Organization and Organs Morphology”. Bangladesh Journal of Pharmacology, vol. 11, no. S1, Mar. 2016, pp. S72-S81, doi:10.3329/bjp.v11iS1.26948.

Issue

Vol. 11 (2016): Special Issue

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).