Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract

Authors

  • Maroua Akacha Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage
  • Karima Lahbib Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage
  • Mejda Daami-Remadi UR13AGR09, Integrated Horticultural Production in the Tunisian Centre East Regional Center of Research on Horticulture and Organic Agriculture of Chott-Mariem, Sousse University, 4042, Chott-Mariem
  • Néziha Ghanem Boughanmi Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage

DOI:

https://doi.org/10.3329/bjp.v11i3.27000

Keywords:

Antibacterial, Antifungal, Anti-inflammatory, Melia azedarach

Abstract

The aim of the present study is to examine the antibacterial, antifungal and anti-inflammatory activities of the ethanolic leaf extract of Melia azedarach. It was tested in vitro for its antibacterial and antifungal activities against E. coli (ATCC 8739), Enterococcus faecalis (Ec P07) and Bacillus subtilis (Bs) bacteria as well as against pathogenic fungi (Alternaria alternate, Fusarium solani, Fusarium oxysporum sp. melonis, F. oxysporum f. sp. lycopersici, F. sambucinum and Botrytis cinerea) with different techniques similtaneously with anti-inflammatory activity with carageaneen method. All tested concentrations of M. azedarach extract showed significant antibacterial and antifungal activities with low IC50 compared to ethanol 95% and a high anti-inflammatory activity compared with indomethacin as drug. Our investigation pointed that M. azedarach could be considered as a good medicinal agent.

Video Clip of Methodology:

Anti-inflammatory effect: 3 min 03 sec   Click to watch 

Downloads

Download data is not yet available.
Abstract
434
Download
262 Read
177 Feature
56

Author Biography

Karima Lahbib, Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage


Downloads

Additional Files

Published

2016-07-05

How to Cite

Akacha, M., K. Lahbib, M. Daami-Remadi, and N. G. Boughanmi. “Antibacterial, Antifungal and Anti-Inflammatory Activities of Melia Azedarach Ethanolic Leaf Extract”. Bangladesh Journal of Pharmacology, vol. 11, no. 3, July 2016, pp. 666-74, doi:10.3329/bjp.v11i3.27000.

Issue

Vol. 11 No. 3 (2016)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).