Chemical and biological investigations of Dillenia indica Linn.

Authors

  • Most. Nazma Parvin Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000
  • Mohammad S. Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000
  • Mohammad S. Islam Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000
  • Mohammad A. Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000

DOI:

https://doi.org/10.3329/bjp.v4i2.2758

Keywords:

Antimicrobial, Antioxidant, Cytotoxicity, Dillenia indica,

Abstract

A total of four compounds namely, lupeol (1), betulinaldehyde (2), betulinic acid (3) and stigmasterol (4) were isolated from the stem extract of Dillenia indica Linn. The structures of the isolated compounds (1-4) were established by extensive spectroscopic studies. The crude methanolic extracts and its n-hexane, carbon tetrachloride, dichloromethane and chloroform soluble partitionates demonstrated weak antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives revealed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives exhibited significant free radical scavenging activity when compared with the standard drug ascorbic acid.   

 

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Author Biographies

Mohammad S. Rahman, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000

Assistant Professor

Mohammad S. Islam, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000

Professor and Chairman

Mohammad A. Rashid, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000

Professor and Dean

References

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Published

2009-07-02

How to Cite

Parvin, M. N., M. S. Rahman, M. S. Islam, and M. A. Rashid. “Chemical and Biological Investigations of Dillenia Indica Linn”. Bangladesh Journal of Pharmacology, vol. 4, no. 2, July 2009, pp. 122-5, doi:10.3329/bjp.v4i2.2758.

Issue

Vol. 4 No. 2 (2009)

Section

Research Articles

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