Antihyperglycemic and anti-oxidant activity of various fraction of Parmotrema hababianum in streptozotocin-induced diabetic rat

Authors

  • Ayyappadasan Ganesan Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215
  • Amutha Mahesh Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215
  • Jeya Prakash Sundararaj Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215
  • Kalaiselvi Mani Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215
  • Ponmurugan Ponnusamy Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215

DOI:

https://doi.org/10.3329/bjp.v11i4.27658

Keywords:

Anti-hyperglycemic, Anti-oxidant, Diabetic, Parmotrema hababianum, Rat, Streptozotocin

Abstract

The core objective of this study was to investigate the in vitro anti-oxidant and antihyperglycemic effect of the ethanol extract of Parmotrema hababianum in streptozocin-induced diabetic rats for 42 days. The extract showed nearly all anti-oxidant activities with maximum presence. The treatment with extract in diabetic rats at the dosage level of 100 and 200 mg/kg, which is compared with diabetic control and glibenclamide at a dosage level of 4 mg/kg and the biochemical parameters such as blood glucose, total cholesterol, triglycerides, HDL, LDL, insulin, total protein, urea and creatinine were assessed. The extract showed positive correlation (p<0.001) in reducing blood glucose level as compared to the control. Moreover, there was a significant (p<0.01) decrease in TC, TG, LDL, SGPT, SGOT, urea and creatinine level and significant (p<0.01) increase in HDL and insulin level. Thus, the results of this study show considerable efficacy in curing diabetes with potent anti-oxidant and anti-hyperglycemic activity.

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Author Biographies

Ayyappadasan Ganesan, Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215

Assistant Professor

Amutha Mahesh, Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215

Student

Jeya Prakash Sundararaj, Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215

Student

Kalaiselvi Mani, Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215

Assistant Professor

Ponmurugan Ponnusamy, Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode 637215

Professor and Head

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Published

2016-12-15

How to Cite

Ganesan, A., A. Mahesh, J. P. Sundararaj, K. Mani, and P. Ponnusamy. “Antihyperglycemic and Anti-Oxidant Activity of Various Fraction of Parmotrema Hababianum in Streptozotocin-Induced Diabetic Rat”. Bangladesh Journal of Pharmacology, vol. 11, no. 4, Dec. 2016, pp. 935-9, doi:10.3329/bjp.v11i4.27658.

Issue

Vol. 11 No. 4 (2016)

Section

Research Articles

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