Antidiarrheal activity of ethanolic bark extract of <i>Mitragyna diversifolia</i>
DOI:
https://doi.org/10.3329/bjp.v4i2.2801Keywords:
Antidiarrheal activity, Barium sulfate milk, Castor oil, Mitragyna diversifoliaAbstract
The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil- induced diarrheal model in rats. These result obtained revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.
Downloads
205
213 Read
5
References
Atta AH, Mouneir SM. Antidiarrheal activity of some Egyptian medicinal plant extracts. J Ethnopharmacol. 2004; 92: 303-09.
Carlos CC, Saniel MC. Etiology and epidemiology of diarrhea. Phillips J Microbio Infect Dis. 1990; 19: 51-53.
Chatterjee TK. Handbook on laboratory mice and rats. 1st ed. Kolkata, Department of Pharmaceutical Technology, Jadavpur University, 1993, p 157.
Gaginella TS, Phillips SF. Ricinoleic acid: Current view of ancient oil. Dig Dis Sci. 1975; 23: 1171-77.
Luderer JR, Dermers IM, Hayes AT. Advances in prostaglandin and thromboxane research. New York, Raven Press, 1980, pp 1633-38.
Mekeon TA, Lin A, Stafford AE. Biosynthesis of ricinoleate in castor oil. Adv Exp Med Biol. 1999, pp. 46437-47.
Ojewole JAO. Evaluation of antidiarrheal, anti-inflammatory and antidiabetic properties of Sclerocarya birrea (A. Rich.) Hochst. stem bark aqueous extract in mice and rats. Phytotherapy Res. 2004; 18: 601-08.
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).