Imiquimod-induced psoriasis-like skin inflammation in mouse model

Authors

  • Irfan Ahmad Rather Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749 http://orcid.org/0000-0003-2752-0519
  • Vivek K. Bajpai Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749 http://orcid.org/0000-0003-0423-6195
  • Jonghun Han Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749
  • Gyeong-Jun Nam Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749

DOI:

https://doi.org/10.3329/bjp.v11i4.28662

Keywords:

Imiquimod, Inflammation, Mouse, Psoriasis, Skin

Abstract

Psoriasis is a skin disorder characterized by skin inflammation and plaques. Induction of psoriasis in animal model include following steps: a) Selection of animal model, b) Hair removing from the back or ear, c) treatment of skin with Aldara, a cream containing 5% imiquimod and d) Observation. Imiquimod-induced skin inflammation in animal model resembles with psoriasis.

Video Clip of Methodology:

Psoriaisis-like skin: 9 min 10 sec   Full Screen   Alternate

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Author Biographies

Irfan Ahmad Rather, Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749

Assistant Professor

Google Scholar Citations

Vivek K. Bajpai, Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749

Assistant Professor

Google Scholar Citations

References

van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. Imiquimod induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009; 182: 5836-45.

Gudjonsson JE, Johnston A, Dyson M, Valdimarsson H, Elder JT. Mouse models of psoriasis. Invest Dermatol. 2007; 127: 1292-308.

Lin YK, Yang SH, Chen CC, Kao HC, Fang JY. Using imiquimod-induced psoriasis-like skin as a model to measure the skin penetration of anti-psoriatic drugs. PLoS ONE. 2015; 10: e0137890.

Lowe NJ, Breeding J, Kean C, Cohn ML. Psoriasiform dermatosis in a rhesus monkey. J Invest Dermatol. 1981; 76: 141-43.

Zanolli MD, Jayo MJ, Jayo JM, Blaine D, Hall J, Jorizzo JL. Evaluation of psoriatic plaques that spontaneously developed in a cynomolgus monkey (Macaca fascicularis). Acta Derm Venereol Suppl (Stockholm). 1989; 146: 58.

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Published

2016-10-01

How to Cite

Rather, I. A., V. K. Bajpai, J. Han, and G.-J. Nam. “Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mouse Model”. Bangladesh Journal of Pharmacology, vol. 11, no. 4, Oct. 2016, pp. 849-51, doi:10.3329/bjp.v11i4.28662.

Issue

Vol. 11 No. 4 (2016)

Section

Visual Experiment

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