Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats
DOI:
https://doi.org/10.3329/bjp.v4i2.2996Keywords:
Cajanus scarabaeoides, Diabetes mellitus, Hypoglycemic, StreptozotocinAbstract
In light of traditional claim of Cajanus scarabaeoides (L) in the treatment of diabetes, we studied the effects of different solvent extracts in normal, glucose over loaded normal and streptozotocin-induced diabetic rats. The methanolic extract (500 mg/kg orally) was produce significantly reduce blood glucose level at normal, glucose over loaded normal rats, and streptozotocin-induced diabetic rats 15 days treatment whereas petroleum ether and chloroform extract (500 mg/kg orally) did not exhibit any significant effect on three groups of rats. Histopathology studies on pancreas streptozotocin-induced diabetic rats inflammatory changes were detected in pancreatic islets results from selectively destroy of insulin producing beta-cells. These changes are inhibited by C. scarabaeoides methanolic extract and gliclazide. The antidiabetic activity of methanolic extract may be due to the presence of flavonoids.
Downloads
263
189 Read
6
References
Amalraj T, Ignacimutu S. Hypoglycemic activity of Cajanus cajan (seeds) in mice. Indian J Exp Biol. 1998; 36: 1032-33.
Babu V, Gangadevi T, Subramoniam A. Antidiabetic activity of ethanol extract of Cassia kleinii leaf in streptozotocin-induced diabetic rats and isolation of an active fraction and toxicity evaluation of the extract. Indian J Pharmacol. 2003; 35: 290-96.
Baily CJ, Day C, Turner SL, Leaterdhale BA. Traditional treatment for diabetes studies in normal and streptozotocin-induced diabetic mice. Diabetes Res. 1985; 2: 81-84.
Bandara T, Rokeya B, Khan S, Ali L, Ekanayake S, Jansz ER, Balasubramanium K. Effects of Gymnema lactiferum leaves on glycemic and lipidemic status in type 2 diabetes subjects. Bangladesh J Pharmacol. 2009; 4: 92-95.
Bhowmik A, Khan LA, Akhter M, Rokeya B. Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats. Bangladesh J Pharmacol. 2009; 4: 110-14.
Davis SN. Insulin, oral hypoglycemic agent and the pharmacology of endocrine pancreas. In: Goodman, Gilman's The pharmacological basis of therapeutics. Brunton LL, Lazo JS, Parker KL (eds). 11th ed. New York, McMillan, 2006.
Fisher, J., Drugs and chemicals that produce diabetes. Trends Pharmacol Sci. 1985; 6: 72-75.
Ivorr MD, Paya M, Villar A. Hypoglycemic and insulin release effect of torlentic acid, a new hypoglycemic natural product. Planta Indica 1988; 54: 282-86.
Jafri MA, Aslam M, Javed K, Singh S. Effect of Punica granatum Linn (flowers) on blood glucose level in normal and alloxan-induced diabetic rats. J Ethnopharmacol. 2000; 70: 30914.
Jaiswal D, Rai PK, Kumar A, Watal G. Study of glycemic profile of Cajanus cajan leaves in experimental rats. Indian J Clin Biochem. 2008; 23: 167-70.
Khandewal KR. Practical pharmacognosy. 14th ed. Pune, Nirali Prakashan, 2005, 14657.
Kritikar KR, Basu BD. India medicinal plants. 2nd ed. Vol 4. Dehradun, Oriental Enterprise, 2003, pp 1129-34.
Mukherjee PK. Extraction of herbal drug and quality control of herbal drug. 2nd ed. New Delhi, Business Horizon Publication, 2005, pp 381-412.
Nanu R, Raghuveer I, Chitme HR, Chandra R. Antidiabetic activity of Nyctanthes arbortristis. Pharmacog Mag. 2008; 4: 335-40.
OECD: Guideline 423 Acute oral toxicity: Environmental Heath and Safety Monograph series on Testing and Assessment No. 24, 2000.
Pattanayak S, Nayak SS, Panda DP. Atimicrobial activity of petroleum ether, chloroform and ethanolic extracts of Cajanus scarabaeoides (L) whole plant. Pharmacol Online 2009; 1: 530-36.
Pattanayak S, Sharma P, Dama G, Nayak SS, Panda DP. Anthelmintic activity of Cajanus scarabaeoides (L). Pharmacology Online 2009; 1: 35-39.
Prajapati DD, Patel NM, Savadi RV, Akki KS, Mruthunjaya K. Alleviation of alloxan-induced diabetes and its complications in rats by Actinodaphne hookeri leaf extract. Bangladesh J Pharmacol. 2008; 3: 102-06.
Rajesh J, Mohammad A, Javed A. Tauorium polium extract effects on pancreatic faction of streptozotocin diabetic rats: A histopathological examination. Iranian Biomed J. 2005; 9: 8185.
Saha BK, Bhuiyan MNH, Mazumder K, Haque KMF. Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action. Bangladesh J Pharmacol. 2009; 4: 79-83.
Shalam M, Harish MS, Farhana SA. Prevention of dexamethasone and fructose-induced insulin resistance in rats by SH-01D, a herbal preparation. Indian J Pharmacol. 2006; 38: 419-22.
Tepne CR, Upaganlawan AB, Thakpe AB, Yeole PG. Preliminary studies on the hypoglycemic activity of Terminalia catappa Linn, leaf extract in normal and alloxan-induced diabetic rats. Phcog Mag. 2007; 11: 21619.
The wealth of India, A dictionary of Indian raw materials and industrial product. Vol 1. New Delhi, CSIR, 2007, p 104.
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
