Hyoscine versus diazepam for the management of true vertigo in the emergency department
DOI:
https://doi.org/10.3329/bjp.v12i2.29962Keywords:
Clinical trial, Diazepam, Emergency department, Hyoscine, True vertigoAbstract
The present study was a double-blind clinical trial to compare the efficiency of hysocine and diazepam in vertigo treatment. Eligible patients (n=69) were randomly divided into 2 groups of 5 mg hyoscine and 10 mg diazepam. Severity of vertigo was measured in supine and sitting position, and while turning the head. Vertigo severity was assessed before, and 1 and 2 hours after administration of the drug. Treatment success rate of diazepam in relieving vertigo in different positions varied between 88.9 and 100%, while this rate was 31.273.5% in hyoscine treatment group (p<0.01). Prescription of diazepam led to complete relief of vertigo in 4063% of the patients, while this rate was only 2.612.5% in hyoscine treatment group (p<0.001). It is likely that diazepam is a better option than hyoscine for management of true vertigo in patients presenting to the emergency department.
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Amini A, Heidari K, Asadollahi S, Habibi T, Shahrami A, Mansouri B, Kariman H. Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety. J Vestib Res. 2014; 24: 39-47.
Gananca MM, Caovilla HH, Gananca FF, Gananca CF, Munhoz MS, da Silva ML, Serafini F. Clonazepam in the pharmacological treatment of vertigo and tinnitus. Int Tinnitus J. 2002; 8: 50-53.
Girardi M, Konrad H. Imbalance and falls in the elderly. In: Otolaryngology: Head and neck surgery. 4th ed. St. Louis, Elsevier-Mosby, 2005, pp 3319-20.
Hain TC, Uddin M. Pharmacological treatment of vertigo. CNS drugs. 2003; 17: 85-100.
Hain TC, Yacovino D. Pharmacologic treatment of persons with dizziness. Neurol Clin. 2005; 23: 831-53.
Kerber KA. Vertigo and dizziness in the Emergency Department. Emerg Med Clin North Am. 2009; 27: 39.
Kerber KA, Baloh RW. Dizziness, vertigo, and hearing loss. In: Neurology in clinical practice. Bradley WG. 5th ed. Burlington, Mass, Butterworth-Heinemann, 2008, pp 50021-22.
King LA, Fortson QCR, Ujvary I, Ramsey J, Nutt DJ. Scopolamine: Useful medicine or dangerous drug? Sci Justice. 2014; 54: 321-22.
Marill KA, Walsh MJ, Nelson BK. Intravenous lorazepam versus dimenhydrinate for treatment of vertigo in the Emergency Department: A randomized clinical trial. Ann Emerg Med. 2000; 36: 310-19.
Marple B, Meyerhoff W. Aging and the auditory and vestibular system. Baileys head and neck surgery otolaryngology. 2nd ed. New York, Lippincott-Raven, 1998, pp 2217-19.
Rahko T, Karma P. Transdermal scopolamine for peripheral vertigo (a double-blind study). J Laryngol Otol. 1985; 99: 653-56.
Renner UD, Oertel R, Kirch W. Pharmacokinetics and pharmacodynamics in clinical use of scopolamine. Ther Drug Monit. 2005; 27: 655-65.
Spinks A, Wasiak J, Bernath V, Villanueva E. Scopolamine (hyoscine) for preventing and treating motion sickness. The Cochrane Library. 2011; 15: CD002851.
Tan J, Yu D, Feng Y, Song Q, You J, Shi H, Yin S. Comparative study of the efficacy of the canalith repositioning procedure versus the vertigo treatment and rehabilitation chair. Acta Oto-laryngologica. 2014; 134: 704-08.
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