Neuroprotective effect of Ziziphus spina-christi on brain injury induced by transient global cerebral ischemia and reperfusion in rat

Authors

  • Mahbubeh Setorki Department of Biology, Izeh Branch, Islamic Azad University, Izeh
  • Zahra Hooshmandi Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj

DOI:

https://doi.org/10.3329/bjp.v12i1.29964

Keywords:

Brain injury, Cerebral ischemia, Cerebral reperfusion, Neuroprotective, Rat, Ziziphus spina-christi

Abstract

This study evaluated the protective effect of Ziziphus spina-christi on the cerebral oxidative stress and damage induced by ischemia. Male Wistar rats were divided randomly into six groups (seven in each group): Control group did not undergo surgery and received distilled water; shame group underwent surgery without ischemia; ischemic group underwent ischemia without any medication; extract-treated groups underwent ischemia and orally received 50, 100, 200 mg/kg/day doses Z. spina-christi extract. After behavioral tests, anti-oxidant capacity and malondialdehyde level of brain and serum were determined. Treatment of ischemic rats with extract significantly increased the frequency of passes through the hidden platform. Z. spina-christi improved motor coordination and balance. Administration of the extract into the ischemic rats prolonged the shortened step-through latency. Z. spina-christi extract significantly reduced the malondialdehyde level of brain and serum and improved serum and brain anti-oxidant capacity.  

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Published

2017-03-03

How to Cite

Setorki, M., and Z. Hooshmandi. “Neuroprotective Effect of Ziziphus Spina-Christi on Brain Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat”. Bangladesh Journal of Pharmacology, vol. 12, no. 1, Mar. 2017, pp. 69-76, doi:10.3329/bjp.v12i1.29964.

Issue

Vol. 12 No. 1 (2017)

Section

Research Articles

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