Bronchodilatory effect of Myxopyrum serratulum in animal model

Authors

  • Vijayalakshmi Maruthamuthu Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational, Research (Centre), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620-024, Tamilnadu http://orcid.org/0000-0001-6151-8004
  • Ruckmani Kandasamy National Facility for Drug Development for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620-024, Tamilnadu

DOI:

https://doi.org/10.3329/bjp.v12i1.30257

Keywords:

Bronchodilatory, Myxopyrum serratulum

Abstract

The plant Myxopyrum serratulum is traditionally claimed to relieve asthma and cough. The present study was undertaken to evaluate the bronchodilatory effect of the methanolic extract of M. serratulum on histamine-induced bronchospasm by in vivo and the inhibitory effect of the extract on histamine-contracted tracheal chain and ileum by in vitro guinea pig model. Additionally, the relaxant effect of four cumulative concentrations of the extract (0.25, 0.5, 0.7 and 1.0 g%) was assessed using precontracted tracheal chain under different conditions. The extract (400 mg/kg) prolonged the preconvulsive time to 102.3 ± 3.8 sec when compared to saline and standard chlorpheniramine maleate as 121.3 ± 4.5 sec (p<0.05). The extract also possessed significant inhibitory effect on histamine-contracted guinea pig ileum and tracheal chain and also exhibited significant relaxation effect on precontracted tracheal chain of guinea pig models contracted by 60 mM KCl (p<0.001) and 10 µM methacholine (p<0.001) when compared with standard theophylline.

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Published

2017-03-03

How to Cite

Maruthamuthu, V., and R. Kandasamy. “Bronchodilatory Effect of Myxopyrum Serratulum in Animal Model”. Bangladesh Journal of Pharmacology, vol. 12, no. 1, Mar. 2017, pp. 84-90, doi:10.3329/bjp.v12i1.30257.

Issue

Vol. 12 No. 1 (2017)

Section

Research Articles

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