A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies

Authors

  • Mubeen Arif Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Furukh Jabeen Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Aamer Saeed Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Irfan Zia Qureshi Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Nadia Mushtaq Department of Chemistry, Quaid-I-Azam University, Islamabad 45320

DOI:

https://doi.org/10.3329/bjp.v12i3.31428

Keywords:

Tetrazolopyridine-acetohydrazide, diabetes mellitus, antidiabetic agent, plasma glucose, glibenclamide.

Abstract

Two new pharmacologically active series of tetrazolopyridine-acetohydrazide conjugates [9 (a-n), 10 (a-n)] were synthesized by reacting a variety of suitably substituted benzaldehydes and isomeric 2-(5-(pyridin-3/4-yl)-2H-tetrazol-2-yl)acetohydrazides (7, 8). The synthesized compounds were analyzed through FTIR, 1H NMR, 13C NMR and elemental techniques. These acetohydrazides were screened for their in vivo antidiabetic activity and molecular docking studies. An excellent agreement was obtained as the best docked poses show-ed important binding features mostly based on interactions due to an oxygen atom and aromatic moieties of the series. The compounds 9a, 9c and 10l were found to be the most active in lowering blood glucose, having the potential of being good antidiabetic agents.

Video Clip of Methodology:

Synthesis of 3/4-(2H-tetrazole-5-yl)pyridine: 1 min 57 sec   Full Screen   Alternate

Downloads

Download data is not yet available.
Abstract
21
Download
12 Read
3

Author Biography

Aamer Saeed, Department of Chemistry, Quaid-I-Azam University, Islamabad 45320

Professor of chemistry

Downloads

Additional Files

Published

2017-09-05

How to Cite

Arif, M., F. Jabeen, A. Saeed, I. Z. Qureshi, and N. Mushtaq. “A New Class of Potential Antidiabetic Acetohydrazides: Synthesis, in Vivo Antidiabetic Activity and Molecular Docking Studies”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Sept. 2017, pp. 319-32, doi:10.3329/bjp.v12i3.31428.

Issue

Vol. 12 No. 3 (2017)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).