Effects of injection Shenkang and alprostadil combination on contrast-induced nephropathy in patient with diabetes complicated with mild to moderate renal insufficiency

Authors

  • Yanfang Zhang Luoyang Vocational and Technical College, 471000, Luoyang, Henan
  • Jianxun Sun Luoyang Vocational and Technical College, 471000, Luoyang, Henan
  • Hui Liu Luoyang Central Hospital, 471000, Luoyang, Henan
  • Xiaolin Zhai Luoyang Central Hospital, 471000, Luoyang, Henan

DOI:

https://doi.org/10.3329/bjp.v12i3.32070

Keywords:

Alprostadil, Contrast-induced nephropathy, Diabetes, Renal insufficiency, Shenkang

Abstract

The diabetic patients (n=109) with mild or moderate renal insufficiency underwent coronary intervention were randomly divided into control group and observation group. The patients in observation group were treated with injection Shenkang and alprostadil before operation. The results showed that the level of serum creatinine, creatinine clearance and blood urea nitrogen had no significant difference (p>0.05) before and postoperative day 1 and day 2 in both groups. However, the value of serum creatinine, creatinine clearance and blood urea nitrogen were significantly different on post-operative day 3 (p<0.05). The incidence of contrast-induced nephropathy was 14.8% in control group, and markedly higher than observation group (3.6%) (p<0.05). Shenkang injection combined with alprostadil injection decreased the incidence of contrast-induced nephropathy in elderly patients with diabetes mellitus complicated with mild to moderate renal insufficiency.

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Published

2017-08-25

How to Cite

Zhang, Y., J. Sun, H. Liu, and X. Zhai. “Effects of Injection Shenkang and Alprostadil Combination on Contrast-Induced Nephropathy in Patient With Diabetes Complicated With Mild to Moderate Renal Insufficiency”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Aug. 2017, pp. 308-12, doi:10.3329/bjp.v12i3.32070.

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Section

Clinical Trial