Protective and curative effects of Cestrum nocturnum on rabbit kidney

Authors

DOI:

https://doi.org/10.3329/bjp.v12i3.32410

Keywords:

C. nocturnum, Nephroprotective, Nephrocurative

Abstract

The objective of current study was to evaluate the nephroprotective and nephrocurative effects of methanolic extract of Cestrum nocturnum leaves in rabbits. Gentamicin (80 mg/kg/day) was administered intramuscularly to induce nephrotoxicity. The induction was assessed by biochemical and histopathological analysis. Methanolic extract (100, 300 or 500 mg/kg) was given orally with gentamicin for 25 days in nephroprotective study whereas in nephrocurative study, gentamicin was administered intramuscularly  for first 10 days and for next 15 days only methanolic extract (100, 300 or 500 mg/kg, orally) was administered. A significant decrease was found in total oxidant status, blood urea nitrogen, serum creatinine and uric acid levels whereas albumin level increased significantly. Histopathological studies also revealed nephroprotective and nephrocurative effects. In conclusion, the methanolic extract of C. nocturnum leaves exhibited significant nephro-protective and nephrocurative effects in experimental animal.

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Author Biography

Uzma Saleem, Faculty of Pharmaceutical Sciences, Govt. College University, Faisalabad

Assistant Professor

Additional Files

Published

2017-08-10

How to Cite

Saleem, U., N. Ali, and B. Ahmad. “Protective and Curative Effects of Cestrum Nocturnum on Rabbit Kidney”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Aug. 2017, pp. 284-91, doi:10.3329/bjp.v12i3.32410.

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Section

Research Articles