Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

Authors

  • Wei Lan The Department of Chinese Materia Medica, Xinjiang Medical University, Urumqi 830 011, XinJiang
  • Hong Ping Zhang The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0003-4312-0099
  • Ying Wang The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0001-8080-1219
  • Min Jiang The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang
  • Qian Li The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0003-3857-1602
  • Dongqing An The Department of Chinese Materia Medica, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0002-2350-0572

DOI:

https://doi.org/10.3329/bjp.v12i3.32413

Keywords:

Antihypertensive, Calcium balance, Endothelin-1, Piperitenone oxide, Secretion, Spontaneously hypertensive rat

Abstract

The purpose of this study was to investigate the antihypertensive mecha-nisms of piperitenone oxide in spontaneously hypertensive rat (SHR). Compared to control SHR, piperitenone oxide reduced the systolic blood pressure and serum endothelium-1 (ET-1). The nitric oxide (NO) production and ET-1 secretion were significantly inhibited in the noradrenaline-exposed bovine aortic endothelial cells. Piperitenone oxide showed endothelium-independent but concentration-dependent relaxation of the artery rings. The responsible mechanisms appear to be related to the modulation of ET-1 and NO levels. The vasorelaxant effect of piperitenone oxide is independent of endothelium-derived mediators, which is associated with interfering intracellular calcium homeostasis by blocking Ca2+ influx, as well as intracellular Ca2+ release.

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Published

2017-09-20

How to Cite

Lan, Wei, et al. “Antihypertensive Effect of Piperitenone Oxide on Spontaneously Hypertensive Rat by Regulating Calcium Balance and Reducing Endothelin-1 Secretion”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Sept. 2017, pp. 341-7, doi:10.3329/bjp.v12i3.32413.

Issue

Vol. 12 No. 3 (2017)

Section

Research Articles

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