Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

Authors

  • Wei Lan The Department of Chinese Materia Medica, Xinjiang Medical University, Urumqi 830 011, XinJiang
  • Hong Ping Zhang The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0003-4312-0099
  • Ying Wang The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0001-8080-1219
  • Min Jiang The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang
  • Qian Li The Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0003-3857-1602
  • Dongqing An The Department of Chinese Materia Medica, Xinjiang Medical University, Urumqi 830 011, XinJiang http://orcid.org/0000-0002-2350-0572

DOI:

https://doi.org/10.3329/bjp.v12i3.32413

Keywords:

Antihypertensive, Calcium balance, Endothelin-1, Piperitenone oxide, Secretion, Spontaneously hypertensive rat

Abstract

The purpose of this study was to investigate the antihypertensive mecha-nisms of piperitenone oxide in spontaneously hypertensive rat (SHR). Compared to control SHR, piperitenone oxide reduced the systolic blood pressure and serum endothelium-1 (ET-1). The nitric oxide (NO) production and ET-1 secretion were significantly inhibited in the noradrenaline-exposed bovine aortic endothelial cells. Piperitenone oxide showed endothelium-independent but concentration-dependent relaxation of the artery rings. The responsible mechanisms appear to be related to the modulation of ET-1 and NO levels. The vasorelaxant effect of piperitenone oxide is independent of endothelium-derived mediators, which is associated with interfering intracellular calcium homeostasis by blocking Ca2+ influx, as well as intracellular Ca2+ release.

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Published

2017-09-20

How to Cite

Lan, W., H. P. Zhang, Y. Wang, M. Jiang, Q. Li, and D. An. “Antihypertensive Effect of Piperitenone Oxide on Spontaneously Hypertensive Rat by Regulating Calcium Balance and Reducing Endothelin-1 Secretion”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Sept. 2017, pp. 341-7, doi:10.3329/bjp.v12i3.32413.

Issue

Vol. 12 No. 3 (2017)

Section

Research Articles

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