Antidiabetic potential of Gaultheria trichophylla in mice

Authors

DOI:

https://doi.org/10.3329/bjp.v12i3.32512

Keywords:

Antidiabetic, Cholesterol, Gaultheria trichophylla, ?-Glucosidase inhibitor

Abstract

This study evaluated Gaultheria trichophylla for its in vitro and in vivo anti-diabetic activity and its effect on biochemical parameters. The extract inhibited ?-glucosidase with IC50 = 17.5 ± 0.1 ?g/mL). The difference of body weight of the extract-treated diabetic groups and diabetic control was significant (p<0.05). The extract-treated and the standard-treated groups showed significant (p<0.001) decrease in the fasting blood glucose levels compared to diabetic control. The extract-treated groups after 15 days of treatment showed a significance (p<0.001 and p<0.05) decrease of the urea and creatinine levels respectively. The extract and standard-treated diabetic groups showed a significant decreased in the serum level of cholesterol, LDL, and triglycerides compared to the diabetic control group (p<0.001). The extract and standard drug showed a significance improvement of HDL level in diabetic mice compared to the diabetic control (p<0.001).

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Author Biography

Fiaz Alam, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060

Assistant Professor

Published

2017-08-15

How to Cite

Alam, F., and Q. N. us Saqib. “Antidiabetic Potential of Gaultheria Trichophylla in Mice”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Aug. 2017, pp. 292-8, doi:10.3329/bjp.v12i3.32512.

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Section

Research Articles