Effect of ginger extract on angiogenesis using CAM assay

Authors

  • Muhammad Farhan Bashir Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan
  • Muhammad Imran Qadir Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan http://orcid.org/0000-0003-1899-5459

DOI:

https://doi.org/10.3329/bjp.v12i3.32616

Keywords:

Angiogenesis, CAM assay, Ginger

Abstract

Angiogenesis performs a critical role in the embryonic growth and several pathological conditions in cancer. This study evaluated the anti-angiogenic properties of the ginger extract using CAM assay. Ginger extract was prepared by methanol. Window was made after 5 days of incubation of eggs and the ginger extract was applied on day 6 at different doses (20, 50, 75 and 150 µL). SPIP software was utilized to investigate the CAM region and diameter of blood vessels. Ginger extract proved anti-angiogenic consequence by decreasing the diameter of CAM of blood vessels. Comparable results were attained at dilution of 150 µL. The anti-angiogenic activity of ginger extract implicates its possible application for diseases where inhibition of blood vessel formation is desired.

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Published

2017-09-25

How to Cite

Bashir, M. F., and M. I. Qadir. “Effect of Ginger Extract on Angiogenesis Using CAM Assay”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Sept. 2017, pp. 348-53, doi:10.3329/bjp.v12i3.32616.

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Section

Research Articles