Pharmacological effects of Cnicus arvensis on the gastrointestinal system

Authors

  • Fatima Saqib Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Sakeena Hassan Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Imran Imran Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Ambreen Aleem Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

DOI:

https://doi.org/10.3329/bjp.v13i1.32905

Keywords:

Cnicus arvensis, Gastrointestinal

Abstract

The current study was conducted to screen the possible pharmacological activity of Cnicus arvensis on the gastrointestinal system. The methanolic extract exerted concentration-dependent (0.01–3.0 mg/mL) spasmolytic effect using isolated tissue preparations of rabbit jejunum and caused relaxation of K+(80 mM)-induced spastic contractions. There was non-parallel shift in Ca++ concentration response curves towards right at tissue bath concentrations of 0.3 and 1.0 mg/mL. The solvent-solvents fractionation revealed domination of spasmolytic effects in petroleum ether fraction as compared to aqueous fraction. The methanolic extract also found to reduce the retching in chicks at 150 mg/kg as compared to chlorpromazine. The methanolic crude extract also found to reduce the number of wet spots using castor oil-induced diarrhea in rat as compare to loperamide. Our results reflected the presence of Ca++ channel blocking activity in methanolic extract, thus rationalizing the medicinal use of C. arvensis in diarrhea and vomiting.

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Published

2018-01-20

How to Cite

Saqib, Fatima, et al. “Pharmacological Effects of Cnicus Arvensis on the Gastrointestinal System”. Bangladesh Journal of Pharmacology, vol. 13, no. 1, Jan. 2018, pp. 16-22, doi:10.3329/bjp.v13i1.32905.

Issue

Vol. 13 No. 1 (2018)

Section

Research Articles

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