Pharmacological validation of the anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal model

Authors

  • Muhammad Jawad Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Mardan
  • Haroon Khan Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Mardan http://orcid.org/0000-0002-1736-4404
  • Samreen Pervez Department of Pharmacy, University of Peshawar 25200, Peshawar
  • Saud S. Bawazeer Department of Pharmaceutical Sciences, Faculty of Pharmacy Umm Al-Qura University, Makkah, P.O. Box 42
  • Tareq Abu-Izneid Department of Pharmaceutical Sciences, Faculty of Pharmacy Umm Al-Qura University, Makkah, P.O. Box 42
  • Muhammad Saeed Department of Pharmacy, University of Peshawar 25200, Peshawar
  • Mohammad A. Kamal 1 King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia 2 Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770; 3 Novel Global Community Educational Foundation, Australia http://orcid.org/0000-0003-0088-0565

DOI:

https://doi.org/10.3329/bjp.v12i4.33182

Keywords:

Anxiolytic, Capsicum annuum, Muscle relaxant, Sedative

Abstract

The current study deals with anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal models. The crude extract was found safe in acute behavior and toxicity studies. However, the n-hexane fraction caused severe acute toxicity. Pretreatment of crude extract and n-hexane fraction elicited marked dose-dependent antianxiety-like effects in elevated plus-maze and dark and light models. The results showed significant (p< 0.05) antianxiety-like effects of crude extract while highly significant (p< 0.001) for n-hexane fraction. Similarly, an effect on muscle coordination was tested in traction model, where both crude extract and n-hexane fraction evoked marked dose-dependent activity. The effect of thiopental-induced sleep test of crude extract and n-hexane fraction was highly significant (p< 0.001). All together, the results revealed potent anxiolytic, muscle relaxant and sedative like activities of C. annuum in animal models and the pharmaco-logically active constituents are mostly non-polar in nature.

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Author Biography

Mohammad A. Kamal, 1 King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia 2 Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770; 3 Novel Global Community Educational Foundation, Australia

Distinguished Adjunct Professor, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

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Published

2017-12-05

How to Cite

Jawad, M., H. Khan, S. Pervez, S. S. Bawazeer, T. Abu-Izneid, M. Saeed, and M. A. Kamal. “Pharmacological Validation of the Anxiolytic, Muscle Relaxant and Sedative Like Activities of Capsicum Annuum in Animal Model”. Bangladesh Journal of Pharmacology, vol. 12, no. 4, Dec. 2017, pp. 439-47, doi:10.3329/bjp.v12i4.33182.

Issue

Vol. 12 No. 4 (2017)

Section

Research Articles

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