Protective role of Nigella sativa in chemotherapy-induced alopecia

Authors

  • Uzma Saleem Faculty of Pharmaceutical Sciences, Government College University-Faisalabad
  • Shakila Sabir Faculty of Pharmaceutical Sciences, Government College University-Faisalabad
  • Bashir Ahmad Riphah Institute of Pharmaceutical Sciences, Riphah International University-Lahore Campus

DOI:

https://doi.org/10.3329/bjp.v12i4.33552

Keywords:

Alopecia, Cyclophosphamide, Decoction, Nigella sativa

Abstract

Chemotherapy-induced alopecia affects the pathological as well as the psychological aspects of the cancer patient. In the present study, the protective role of Nigella sativa was evaluated in both adult and newborn albino rats. The anagen phase was first induced. N. sativa oil, N. sativa decoction (5%, 10% and 15%) and minoxidil lotion (standard) were applied daily to the rats two days after the depilation. During the anagen VI phase of the hair follicles, alopecia was induced by giving cyclophosphamide 125 mg/kg, ip to the adult rat and 50 mg/kg to the newborn rats. Cyclophosphamide-induced the alopecia to the whole depilated area of skin in adult rat while alopecia totalis was observed in the newborn rat disease control group. N. sativa oil, N. sativa decoction (5%) showed a significant protective effect against cyclophosphamide-induced alopecia. In conclusion, it is evident that N. sativa provides significant protection against chemotherapy-induced alopecia.

Video Clip of Methodology:

1 min 43 sec:   Click to watch

Downloads

Download data is not yet available.
Abstract
38
Download
29 Read
11

Author Biography

Uzma Saleem, Faculty of Pharmaceutical Sciences, Government College University-Faisalabad

Assistant Professor

Downloads

Additional Files

Published

2017-12-17

How to Cite

Saleem, U., S. Sabir, and B. Ahmad. “Protective Role of Nigella Sativa in Chemotherapy-Induced Alopecia”. Bangladesh Journal of Pharmacology, vol. 12, no. 4, Dec. 2017, pp. 455-62, doi:10.3329/bjp.v12i4.33552.

Issue

Vol. 12 No. 4 (2017)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).