Protective role of Nigella sativa in chemotherapy-induced alopecia

Authors

  • Uzma Saleem Faculty of Pharmaceutical Sciences, Government College University-Faisalabad
  • Shakila Sabir Faculty of Pharmaceutical Sciences, Government College University-Faisalabad
  • Bashir Ahmad Riphah Institute of Pharmaceutical Sciences, Riphah International University-Lahore Campus

DOI:

https://doi.org/10.3329/bjp.v12i4.33552

Keywords:

Alopecia, Cyclophosphamide, Decoction, Nigella sativa

Abstract

Chemotherapy-induced alopecia affects the pathological as well as the psychological aspects of the cancer patient. In the present study, the protective role of Nigella sativa was evaluated in both adult and newborn albino rats. The anagen phase was first induced. N. sativa oil, N. sativa decoction (5%, 10% and 15%) and minoxidil lotion (standard) were applied daily to the rats two days after the depilation. During the anagen VI phase of the hair follicles, alopecia was induced by giving cyclophosphamide 125 mg/kg, ip to the adult rat and 50 mg/kg to the newborn rats. Cyclophosphamide-induced the alopecia to the whole depilated area of skin in adult rat while alopecia totalis was observed in the newborn rat disease control group. N. sativa oil, N. sativa decoction (5%) showed a significant protective effect against cyclophosphamide-induced alopecia. In conclusion, it is evident that N. sativa provides significant protection against chemotherapy-induced alopecia.

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Author Biography

Uzma Saleem, Faculty of Pharmaceutical Sciences, Government College University-Faisalabad

Assistant Professor

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Additional Files

Published

2017-12-17

How to Cite

Saleem, U., S. Sabir, and B. Ahmad. “Protective Role of Nigella Sativa in Chemotherapy-Induced Alopecia”. Bangladesh Journal of Pharmacology, vol. 12, no. 4, Dec. 2017, pp. 455-62, doi:10.3329/bjp.v12i4.33552.

Issue

Vol. 12 No. 4 (2017)

Section

Research Articles

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