Potential of Mimosa pudica leaf in the treatment of ulcerative colitis in rat

Authors

  • Bharati Zaware Department of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India http://orcid.org/0000-0003-0881-6576
  • Ritu Gilhotra Department of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India
  • Sanjay Ravindra Chaudhari Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune 411019, Maharashtra, India

DOI:

https://doi.org/10.3329/bjp.v13i3.35648

Keywords:

Mimosa pudica, Ulcerative colitis

Abstract

The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of Mimosa pudica. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with M. pudica ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of M. pudica leaf is effective in the treatment of ulcerative colitis.

Video Clip of Methodology:

Embedding or block making: 24 sec  Click to watch

Tissue processing: 19 sec   Click to watch

Section cutting: 33 sec   Click to watch

Downloads

Download data is not yet available.
Abstract
33
Download
21 Read
18

Downloads

Additional Files

Published

2018-08-14

How to Cite

Zaware, B., R. Gilhotra, and S. R. Chaudhari. “Potential of Mimosa Pudica Leaf in the Treatment of Ulcerative Colitis in Rat”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, Aug. 2018, pp. 241-7, doi:10.3329/bjp.v13i3.35648.

Issue

Vol. 13 No. 3 (2018)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).