Potential of Mimosa pudica leaf in the treatment of ulcerative colitis in rat

Authors

  • Bharati Zaware Department of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India http://orcid.org/0000-0003-0881-6576
  • Ritu Gilhotra Department of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India
  • Sanjay Ravindra Chaudhari Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune 411019, Maharashtra, India

DOI:

https://doi.org/10.3329/bjp.v13i3.35648

Keywords:

Mimosa pudica, Ulcerative colitis

Abstract

The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of Mimosa pudica. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with M. pudica ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of M. pudica leaf is effective in the treatment of ulcerative colitis.

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Published

2018-08-14

How to Cite

Zaware, B., R. Gilhotra, and S. R. Chaudhari. “Potential of Mimosa Pudica Leaf in the Treatment of Ulcerative Colitis in Rat”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, Aug. 2018, pp. 241-7, doi:10.3329/bjp.v13i3.35648.

Issue

Section

Research Articles