Effect of sevoflurane postconditioning on myocardial oncosis and autophagy in ischemia-reperfusion injury in isolated rat heart

Authors

  • Qi Feng Tang Department of Anesthesiology, Suzhou BenQ Medical Center, Nanjing Medical University, Suzhou 215008, Jiangsu, China http://orcid.org/0000-0003-4859-0743
  • Yang Xie Department of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215006, Jiangsu, China
  • Hong Xie Department of Anesthesiology and Critical Care, The Second Affiliate Hospital of Soochow University, Suzhou 215008, Jiangsu, China
  • Wen Qiang Jiang Department of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215006, Jiangsu, China
  • Zhi Yuan Fang Department of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215006, Jiangsu, China

DOI:

https://doi.org/10.3329/bjp.v13i3.36437

Keywords:

Heart, Ischemia-reperfusion, Myocardial oncosis, Sevoflurane

Abstract

The effects of sevoflurane postconditioning on myocardial oncosis and autophagy were studied in 32 isolated rat heart of ischemia-reperfusion injury. The hearts were perfused by: a) Sham surgery group, b) simple sevoflurane group, c) simple ischemia-reperfusion group (I/R) group, and d) sevoflurane postconditioning group. The ratios between the gray density values of the target bands to the gray density value of GADPH were used to reflect the Beclin-1, LC3II/I, and porimin expression levels. The LC3II/I level in the sevoflurane postconditioning group was lower than the level in the I/R group. The porimin level in the sevoflurane postconditioning group was lower than the level in the I/R group. The myocardial infarction range in the sevoflurane postconditioning group (33 ± 5%) was significantly diminished compared with the range in the I/R group (53 ± 6%) (p<0.05). Sevoflurane decreased the occurrence of oncosis and alleviated myocardial ischemia-reperfusion injury by inhibiting MPTP opening.

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Published

2018-08-28

How to Cite

Tang, Q. F., Y. Xie, H. Xie, W. Q. Jiang, and Z. Y. Fang. “Effect of Sevoflurane Postconditioning on Myocardial Oncosis and Autophagy in Ischemia-Reperfusion Injury in Isolated Rat Heart”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, Aug. 2018, pp. 255-63, doi:10.3329/bjp.v13i3.36437.

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Section

Research Articles