Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

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DOI:

https://doi.org/10.3329/bjp.v13i3.36621

Keywords:

Berberis baluchistanica, Gentamicin, Nephroprotective

Abstract

The present study was conducted to explore the protective effect of B. baluchistanica against gentamicin-induced renal toxicity in rabbits. Phytochemical investigations lead to the isolation of berberine and palmatine. The crude hydro-methanolic extract at various doses (100, 200 and 300 mg/kg body weight) elicited strong nephroprotective effects by restoring various biomarkers which were deranged by gentamicin  such as creatinine, urea, serum uric acid levels (p<0.001) in plasma and urine output creatinine clearance, urinary protein and γ-glutamyl transferase level (p<0.001) in urine in a dose dependent manner. The mediators involved in oxidative stress such malondialdehyde, reduced glutathione, glutathione peroxidase, and catalase levels were significantly (P˂0.05-0.001) modulated in kidney tissue homogenate. Correspondingly, there is a significant (P<0.05) recovery in kidney weight and % loss in body weight compare to GM group. From these results, it is possible that B. baluchistanica exhibited protective effect mediated through the presence of berberine  and palmatine.

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Published

2018-07-21

How to Cite

Pervez, S., M. Saeed, H. Khan, M. Shahid, and I. Ullah. “Nephroprotective Effect of Berberis Baluchistanica Against Gentamicin-Induced Nephrotoxicity in Rabbit”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, July 2018, pp. 222-30, doi:10.3329/bjp.v13i3.36621.

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Section

Research Articles